 | | Vol. 3.41 – 20 October, 2022 |
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| Scientists devised a pooled human organoid-panel of steatohepatitis to investigate the impact of metabolic status on genotype-phenotype association.
[Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors showed that human induced salivary glands generated from hiPSCs can be infected with SARS-CoV-2.
[Nature Cell Biology] |
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| Researchers established a human retinal organoid system reproducing several parameters of the human retina, including some within the macula, to model a complex combination of photoreceptor and glial pathologies.
[Nature Communications] |
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| Investigators established intestinal organoids from tamoxifen-inducible intestinal epithelial cell-specific superoxide dismutase 1 (SOD1) knockout mice to explore the regulation of intestinal homeostasis.
[Cell Death & Disease] |
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| The authors analyzed 3D retinal organoids generated from Usher type 1B retinitis pigmentosa patient-derived induced pluripotent stem cells.
[Stem Cell Reports] |
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| Researchers reprogramed mitochondria-rich human urine cells into expandable intermediate mesoderm progenitor like cells, which in turn generated nephron progenitors and formed kidney organoids in both 2D and 3D cultures.
[Cell & Bioscience] |
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| Investigators established a scaffold-free protocol to generate multicellular, beating human cardiac microtissues in vitro from hiPSCs, namely human organotypic cardiac microtissues.
[Scientific Reports] |
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| Scientists constructed a 3D testicular organoid model using primary testicular cells from adult BALB/C mice.The organoid system had a blood-testis barrier-like structure and could synthesize testosterone.
[Virologica Sinica] |
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| A pancreatic cancer organoid culture from a genetically engineered pancreatic cancer murine model was established and co-cultured with autologous peripheral blood lymphocytes to induce a tumor-specific T cell response to pancreatic cancer.
[Biochemistry and Biophysics Reports] |
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| Investigators summarize how such organoid models can complement classical approaches to accelerate neurological research.
[Nature Reviews Neurology] |
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| Harvard University announced the latest gift of $350 million from Hansjörg Wyss, an entrepreneur and philanthropist, to support the continued mission of the Wyss Institute for Biologically Inspired Engineering at Harvard University.
[Wyss Institute] |
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| December 8 – 10, 2022
Los Angeles, California, United States |
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| | Helmholtz Munich – Oldenburg, Germany |
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| | Terrence Donnelly Centre for Cellular and Biomolecular Research, U of T – Toronto, Ontario, Canada |
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| | The Foundation for Liver Research – London, England, United Kingdom |
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| | Cancer Research Center of Lyon – Lyon, France |
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| | University of Miami – Miami, Florida, United States |
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