 | | Vol. 3.42 – 27 October, 2022 |
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| Researchers retrospectively quantified apoptotic responses and tumor-stromal cell proportions in patient-derived organoids via 3D immunofluorescence imaging through annexin A5, α-smooth muscle actin, and cytokeratin 19 levels.
[Journal of Clinical Investigation] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Lineage tracing experiments showed that upon genetic or pharmacologic FoxO1 ablation, the Paneth/goblet lineage can undergo conversion to the insulin lineage.
[Journal of Clinical Investigation] |
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| To assess the influence of mechanical cues on enteropathogen invasion, investigators combined computational imaging with a mechanically active gut-on-a-chip.
[Science Advances] |
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| Scientists developed an integrative pharmacogenomics pipeline to identify compounds similar to dipyridamole at the level of drug structure, cell sensitivity, and molecular perturbation.
[Nature Communications] |
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| Researchers used single-cell RNA sequencing to profile cells from normal endometrium, atypical endometrial hyperplasia, and endometrioid endometrial cancer.
[Nature Communications] |
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| Investigators introduced OrganoidDB, a comprehensive resource for the multi-perspective exploration of the transcriptomes of organoids.
[Nucleic Acids Research] |
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| The authors generated a series of primary gastric cancer models in mice with genome-edited gastric organoids.
[Cell Reports] |
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| Researchers reported generation of a patient-derived FGFR2 fusion-positive intrahepatic cholangiocarcinoma model system consisting of a cell line, organoid, and xenograft.
[npj Precision Oncology] |
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| Investigators established direct 3D co-cultures of primary pancreatic ductal adenocarcinoma organoids and patient-matched cancer-associated fibroblasts.
[Journal of Experimental & Clinical Cancer Research] |
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| Through organoid experiments, scientists found that Zymosan-A promoted the proliferation and differentiation of intestinal stem cells after ionizing radiation.
[Cell Death & Disease] |
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| Researchers established a patient-derived parathyroid organoid model representing human parathyroid tissue. Hyperplastic parathyroid tissue was dispersed, and parathyroid organoids were cultured and characterized.
[Stem Cell Reports] |
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| Scientists reported a self-organizing 3D neural tube organoid model derived from single mESCs that exhibited an in vivo-like tissue architecture, cell type composition, and anterior-posterior patterning.
[Development] |
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| Successful patient-derived organoids were phenotypically characterized by immunohistochemistry and genotypically by gene fusion analysis, and by targeted and whole-exome sequencing.
[Oral Oncology] |
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| Scientists present the state of the art of 3D bioprinted cancer modeling, focusing on the biological processes that underlie the molecular mechanisms involved in cancer progression and treatment response as well as on proteomic and genomic signatures.
[Nature Reviews Cancer] |
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| MiraCosta College has received a state grant of almost $2.9 million that will be used to offer internships, mentoring, and financial support to encourage students to pursue careers in stem cell research and manufacturing.
[MiraCosta College] |
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| December 10 – 14, 2022
Maui, Hawaii, United States |
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| | University of Copenhagen – Copenhagen, Denmark |
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| | Helmholtz Munich – Oldenburg, Germany |
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| | Terrence Donnelly Centre for Cellular and Biomolecular Research, U of T – Toronto, Ontario, Canada |
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| | The Foundation for Liver Research – London, United Kingdom |
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| | Cancer Research Center of Lyon – Lyon, France |
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