Organoid News Volume 3.44 | Nov 10 2022

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    2022-11-10 | ON 3.44


    Organoid News by STEMCELL Technologies
    Vol. 3.44 – 10 November, 2022
    TOP STORY

    FOXA2 Drives Lineage Plasticity and KIT Pathway Activation in Neuroendocrine Prostate Cancer

    Using single-cell multiomics analyses, researchers investigated the dynamics of cellular heterogeneity, transcriptome regulation, and microenvironmental factors in 107,201 cells from genetically engineered mouse prostate cancer samples with complete time series of tumor evolution seen in patients.
    [Cancer Cell]

    Full ArticleGraphical Abstract
    Watch the Webinar On-Demand: “Re-Creating Disease with Kidney Organoids and CRISPR-Cas9”
    PUBLICATIONSRanked by the impact factor of the journal

    Spatial Dynamic Metabolomics Identifies Metabolic Cell Fate Trajectories in Human Kidney Differentiation

    Using a multi-omics platform to study cell-type-specific dynamics in metabolism in complex tissues, scientists described the metabolic trajectories during nephrogenesis in the developing human kidney.
    [Cell Stem Cell]

    Full ArticleGraphical Abstract

    CROCCP2 Acts as a Human-Specific Modifier of Cilia Dynamics and mTOR Signaling to Promote Expansion of Cortical Progenitors

    The authors focused on CROCCP2 a hominid-specific gene duplicate from ciliary rootlet coiled coil (CROCC) that encoded the major component of the ciliary rootlet and found that CROCCP2 was highly expressed in the human fetal brain and not in other primate species.
    [Neuron]

    Full ArticleGraphical Abstract

    Mapping Prohormone Processing by Proteases in Human Enteroendocrine Cells Using Genetically Engineered Organoid Models

    Human gut organoids in which enteroendocrine cells (EECs) could efficiently be induced were subjected to CRISPR-Cas9–mediated modification of EEC-expressed endopeptidase and exopeptidase genes.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Full Article

    Directed Evolution Identifies High-Affinity Cystine-Knot Peptide Agonists and Antagonists of Wnt/β-Catenin Signaling

    In an alveolosphere organoid model, the cystine-knot peptide agonists induced alveolar stem cell activity. They also stimulated growth in primary human intestinal organoids.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Full Article

    SARS-CoV-2 Infects Human Brain Organoids Causing Cell Death and Loss of Synapses That Can Be Rescued by Treatment with Sofosbuvir

    To experimentally determine whether SARS-CoV-2 could replicate in and affect human brain cells, investigators infected iPSC-derived human brain organoids. They showed that SARS-CoV-2 can productively replicate and promote death of neural cells, including cortical neurons.
    [PLoS Biology]

    Full Article

    Lateral Plate Mesoderm Cell-Based Organoid System for NK Cell Regeneration from Human Pluripotent Stem Cells

    Researchers developed an embryoid body-free, organoid aggregate method for NK cell regeneration from hPSCs. In a short time-window of 27-day induction, millions of hPSC input could output over billions of iNK cells without the necessity of NK cell expansion feeders.
    [Cell Discovery]

    Full Article

    Immersion Bioprinting of Hyaluronan and Collagen Bioink-Supported 3D Patient-Derived Brain Tumor Organoids

    The authors described an improvement to a previous bioprinting approach, based on rheological assessment of previous gelatin baths versus newer hyaluronic acid support baths, combined with morphological assessment of immersion bioprinted organoids.
    [Biomedical Materials]

    Abstract

    Modeling Human Gonad Development in Organoids

    Scientists utilized the 3D hPSC organoid culture in mini-spin bioreactors. Relying on intrinsic self-organizing and differentiation capabilities of stem cells, and explored whether organoids could mimic the development of human embryonic and fetal gonad.
    [Journal of Tissue Engineering and Regenerative Medicine]

    Abstract
    ISSCR 2022 Neural Cell Culture Model Webinar - 728x90
    REVIEWS

    Can Kidney Organoid Xenografts Accelerate Therapeutic Development for Genetic Kidney Disorders?

    Under in vitro conditions, kidney organoids remain developmentally immature, develop scarce vasculature, and may contain undesired off-target cell types.
    [Journal of the American Society of Nephrology]

    Abstract

    The Organoid as Reliable Cancer Modeling in Personalized Medicine; Applicable in Precision Medicine of Head and Neck Squamous Cell Carcinoma?

    Organoids allow scientists to investigate the biopathogenesis of cancer, tumor cell behavior, and drug screening in a living biobank according to the specific genetic profile of patients.
    [The Pharmacogenomics Journal]

    Abstract
    INDUSTRY AND POLICY NEWS

    UCI Earns Designation as CIRM Alpha Clinic with Five-Year, $8 Million Grant

    With a five-year, $8 million grant from the California Institute for Regenerative Medicine, the University of California, Irvine has earned designation as one of CIRM’s Alpha Clinics, with the goal of accelerating the development of promising stem cell and gene therapies.
    [University of California, Irvine]

    Press Release
    FEATURED EVENT

    Drug Delivery to the Brain: Challenges and Progress

    January 23 – 25, 2023
    Breckenridge, Colorado, United States

    > See All Events

    JOB OPPORTUNITIES

    Technician – Hydrogels and Beta Cells

    King’s College London – London, England, United Kingdom

    Postdoctoral Position – Organoid Models of Regeneration and Disease

    Shanghai Tech University – Shanghai, China

    Lecturer – Cell and Developmental Biology

    Imperial College London – London, England, United Kingdom

    Postdoctoral Scientist – Regenerative Therapy

    Berlin Institute of Health – Berlin, Germany

    Scientist – iPSC and CRISPR

    Icahn School of Medicine at Mount Sinai – New York, New York, United States

    > See All Jobs

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