 | | Vol. 3.45 – 17 November, 2022 |
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| Investigators described a step-wise, directed-differentiation protocol in which organoids are generated from iPSCs committed to mesenchymal, endothelial, and hematopoietic lineages.
[Cancer Discovery] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers addressed the molecular mechanisms underlying the association between Mitotic Arrest Deficient-1 Like 1 (MAD1L1) and the pathology of schizophrenia by examining the role of MAD1 in key neurodevelopmental processes in mice and human organoids.
[Molecular Psychiatry] |
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| Using a genome-wide CRISPR-Cas9-mediated screen, the authors identified tissue factor pathway inhibitor (TFPI) as a host receptor for Toxin B 4.
[Nature Communications] |
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| Investigators showed that TEA/TEF-domain transcription factors (TEAD) palmitoylation inhibitor MGH-CP1 and analogs blocked cancer cell “stemness”, organ overgrowth, and tumor initiation in vitro and in vivo.
[Nature Communications] |
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| Researchers described a self-organized human multilineage organoid that recreated the co-emergence of pro-epicardium, septum transversum mesenchyme, and liver bud.
[Nature Communications] |
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| The authors generated induced pluripotent stem cells (iPSC) from five patients with major depressive disorders with suicidal behavior and differentiated the iPSCs into GABAergic interneurons and ventral forebrain organoids.
[EMBO Molecular Medicine] |
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| Multiplatform analyses of endocrine patient-derived organoids and applications in oncoimmunology, near-infrared autofluorescence, and radiosensitization studies under 3D in vitro conditions were performed.
[Surgery] |
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| Investigators monitored the influence of small microplastics on human colon cells and human colon organoids, and also examined their toxicity and changes in gene expression in vivo in a mouse model.
[Tissue Engineering and Regenerative Medicine] |
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| Researchers established a robust differentiation method into suspension-cultured human intestinal organoids by seeding dissociated cells on a spheroid-forming plate.
[Cell Reports Methods] |
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| The authors address the use of 3D culture systems to integrate tissue mechanics to mimic cardiac remodeling.
[Nature Reviews Cardiology] |
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| Scientists summarize in vitro (2D cell-culture/co-culture, 3D spheroid/organoid/liver-on-a-chip) models as well as in vivo (genetically/dietary/chemically induced fatty liver disease) research models.
[Life Sciences] |
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| NTT Research, Inc., announced that its Medical & Health Informatics Lab had entered a three-year joint research agreement with the Harvard John A. Paulson School of Engineering and Applied Sciences.
[NTT Research, Inc.] |
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| February 5 – 8, 2023
Keystone, Colorado, United States |
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| | STEMCELL Technologies, Inc. – Boston, Massachusetts, United States |
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| | University of Bristol – Bristol, England, United Kingdom |
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| | King’s College London – London, England, United Kingdom |
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| | Shanghai Tech University – Shanghai, China |
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| | Imperial College London – London, England, United Kingdom |
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Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
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Pancreatic Cell News
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