 | | Vol. 3.46 – 24 November, 2022 |
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| Investigators demonstrated that chemotherapy-induced tumor cell death in patient-derived colorectal tumor organoids caused ATP release triggering P2X4 to mediate an mTOR-dependent pro-survival program in neighboring cancer cells, which rendered surviving tumor epithelia sensitive to mTOR inhibition.
[Nature] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists combined tissue reconstitution and quantitative microscopy to show that tissue topology and shape was governed by two distinct modes of topological transitions.
[Nature Physics] |
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| The authors showed that human astrocytes could be directly reprogrammed into early neuroectodermal cells via the overexpression of OCT4, the suppression of p53 and the provision of the small molecules CHIR99021, SB431542, RepSox, and Y27632.
[Nature Biomedical Engineering] |
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| Researchers used human cortical organoids to study the effects of alcohol on neurogenesis and validated their findings in primary human fetal neurons.
[Molecular Psychiatry] |
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| The authors reported the generation of transplantable thyroid organoids derived from human embryonic stem cells capable of restoring plasma thyroid hormone in athyreotic mice.
[Nature Communications] |
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| Scientists characterized the structural and functional interaction between CREB-binding protein (CBP)/E1A-binding protein p300 and heat-shock factor 2 (HSF2), a tuner of brain cortical development and major player in prenatal stress responses in the neocortex.
[Nature Communications] |
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| In vitro, the treatment of L. salivarius supernatant was confirmed to promote the intestinal organoids’ size, budding, and LGR5 expression.
[MSystems] |
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| Investigators highlighted the important role of the tyrosine hydroxylase–dopamine pathway in the pathogenesis of Parkinson’s disease.
[Cellular and Molecular Life Sciences] |
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| Researchers described the development of a 3D human cell-based in vitro assay for the investigation of nephrotoxicity, using RPTEC-TERT1 cells.
[PLoS One] |
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| Investigators focus on the construction of brain organoids and review the application of brain organoids in disease modeling and drug screening.
[Frontiers in Cell and Developmental Biology] |
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| Scientists discuss the variations and limitations of human intestinal organoids (HIOs), but also how HIOs have allowed for the cultivation of previously uncultivatable viruses and how they have offered insight into tropism, entry, replication kinetics, and host-pathogen interactions.
[American Journal of Physiology-Gastrointestinal and Liver Physiology] |
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| The authors present stem cells, scaffold materials and methods for the construction of organoids for plastic surgery, and summarize their research progress in plastic surgery in recent years.
[Aesthetic Plastic Surgery] |
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| Spearheading work to make cell manufacturing process discoveries is Associate Professor Zhen Ma. He will be working with a newly awarded $500,000 National Science Foundation future manufacturing seed grant and coordinating the project with bioengineering experts at the Rochester Institute of Technology.
[Syracuse University News] |
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| February 5 – 8, 2023
Keystone, Colorado, United States |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | Philipps-University Marburg – Marburg, Germany |
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| | STEMCELL Technologies, Inc. – Boston, Massachusetts, United States |
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| | University of Bristol – Bristol, England, United Kingdom |
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| | Shanghai Tech University – Shanghai, China |
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