 | | Vol. 3.47 – 1 December, 2022 |
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| Investigators demonstrated that chemotherapy-induced tumor cell death in patient-derived colorectal tumor organoids caused ATP release triggering P2X4 to mediate an mTOR-dependent pro-survival program in neighboring cancer cells, which rendered surviving tumor epithelia sensitive to mTOR inhibition.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists combined tissue reconstitution and quantitative microscopy to show that tissue topology and shape were governed by two distinct modes of topological transitions.
[Nature Physics] |
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| The authors showed that human astrocytes could be directly reprogrammed into early neuroectodermal cells via the overexpression of OCT4, the suppression of p53 and the provision of the small molecules CHIR99021, SB431542, RepSox, and Y27632.
[Nature Biomedical Engineering] |
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| Researchers used human cortical organoids to study the effects of alcohol on neurogenesis and validated their findings in primary human fetal neurons.
[Molecular Psychiatry] |
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| To investigate the pathophysiology of early development in Tourette Syndrome (TS), iPSC-derived basal ganglia organoids from TS patients and healthy controls were compared on multiple levels of measurement and analysis.
[Molecular Psychiatry] |
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| Researchers presented a soft resistive force-sensing diaphragm based on ultrasensitive resistive nano-cracked platinum film, which could be integrated into an all-soft culture well via an oxygen plasma-enabled bonding process.
[Nature Communications] |
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| Scientists described an organ-on-a-chip microfluidic culture model of the human vaginal mucosa that was lined by hormone-sensitive, primary vaginal epithelium interfaced with underlying stromal fibroblasts, which sustained a low physiological oxygen concentration in the epithelial lumen.
[Microbiome] |
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| The authors found that pharmacological induction of ferroptosis in pancreatic organoids derived from the LsL-KRASG12D expressing mouse model was only effective in combination with ferroptosis suppressor protein inhibition.
[Cell Death & Differentiation] |
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| Investigators performed microarray, RNA-seq, and ATAC-seq analyses of the murine collagen sphere in comparison with Matrigel organoid and fetal enterospher.
[Inflammation and Regeneration] |
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| BRAFV600E tumors and patient-derived organoids (PDOs) expressed high levels of glutamate-cysteine ligase (GCL). Deletion of GCL in BRAFV600E PDOs strongly reduced their capacity to form distant liver and lung metastases but did not affect peritoneal metastasis outgrowth.
[Cell Reports] |
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| Investigators used time-lapse microscopy to track all cells in crypts of growing mouse intestinal organoids for multiple generations, allowing full reconstruction of the underlying lineage dynamics in space and time.
[eLife] |
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| The authors developed a multiplex platform that automated the culture of individual organoids in isolated microenvironments at user-defined media flow rates.
[Scientific Reports] |
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| Bladder organoids cultured using bladder specimens from enhanced green fluorescent protein transgenic mice were engrafted to replace proximal colon epithelium stripped from an approximately 1 cm long target site in syngeneic wild-type recipient mice by exposure to ethylenediaminetetraacetic acid.
[Pediatric Surgery International] |
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| The authors revise the current knowledge on organoid technology and its use in healthcare and research, describe the male reproductive system organoids and other biomaterials already developed, and discuss their current application.
[WIRES Mechanisms of Disease] |
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| Spearheading work to make cell manufacturing process discoveries is Associate Professor Zhen Ma. He will be working with a newly awarded $500,000 National Science Foundation (NSF) future manufacturing seed grant and coordinating the project with bioengineering experts at the Rochester Institute of Technology.
[Syracuse University News] |
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| February 5 – 8, 2023
Keystone, Colorado, United States |
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| | University of Cambridge – Cambridge, England, United Kingdom |
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| | Roche – Basel, Switzerland |
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| | University of Kent – Canterbury, England, United Kingdom |
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| | Memorial Sloan Kettering Cancer Center – New York, New York, United States |
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| | Centre for Oncology and Immunology – Hong Kong, Hong Kong |
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