Organoid News Volume 3.48 | Dec 08 2022

    By
    Laurisa Dohm
    -
    0
    20








    2022-12-08 | ON 3.48


    Organoid News by STEMCELL Technologies
    Vol. 3.48 – 8 December, 2022
    TOP STORY

    SARS-CoV-2 Replication in Airway Epithelia Requires Motile Cilia and Microvillar Reprogramming

    Using primary nasal epithelial organoid cultures, researchers found the SARS-CoV-2 attached to motile cilia via the ACE2 receptor, then traversed the mucus layer, using motile cilia as tracks to access the cell body.
    [Cell]

    AbstractFull Article
    Abstract
    ISSCR 2022 Neural Cell Culture Model Webinar - 728x90
    PUBLICATIONSRanked by the impact factor of the journal

    Organoid Modeling of Human Fetal Lung Alveolar Development Reveals Mechanisms of Cell Fate Patterning and Neonatal Respiratory Disease

    Researchers identified an alveolar-fated epithelial progenitor in human fetal lungs, which grew as self-organizing organoids that modeled key aspects of cell lineage commitment.
    [Cell Stem Cell]

    Full ArticleGraphical Abstract

    LY6D Marks Pre-Existing Resistant Basosquamous Tumor Subpopulations

    Using computational tools, organoids, and spatial tools, the authors showed that LY6D+ basosquamous cells represented a persister population lying on a central node along the skin lineage-associated spectrum of epithelial states.
    [Nature Communications]

    Full Article

    Epithelial TGFβ Engages Growth-Factor Signaling to Circumvent Apoptosis and Drive Intestinal Tumorigenesis with Aggressive Features

    Scientists identified a cohort of early-stage colorectal tumors, with aggressive features and a propensity to disseminate early, that were characterized by high epithelial cell-intrinsic TGFβ signaling.
    [Nature Communications]

    Full Article

    Human Placental Barrier-Brain Organoid-on-a-Chip for Modeling Maternal PM2.5 Exposure

    Researchers constructed a placental barrier-brain organoid-on-a-chip model, which enabled them to investigate the effects of maternal PM2.5 exposure on the human fetal system including the placental barrier and fetal brain.
    [Science of the Total Environment]

    AbstractGraphical Abstract

    The Chromatin Remodeler CHD6 Promotes Colorectal Cancer Development by Regulating TMEM65-Mediated Mitochondrial Dynamics via EGF and Wnt Signaling

    The authors reported that CHD6 was highly expressed in colorectal cancer, and that CHD6 knockdown inhibited cancer cell proliferation, migration, invasion, and tumorigenesis.
    [Cell Discovery]

    Full Article

    Dialysis Based-Culture Medium Conditioning Improved the Generation of Human Induced Pluripotent Stem Cell Derived-Liver Organoid in a High Cell Density

    Investigators developed a simple dialysis-based medium conditioning that fully utilized growth factors accumulation to improve hepatic differentiation of human iPSCs at a high cell density.
    [Scientific Reports]

    Full Article

    Ex Vivo Chemosensitivity Assay Using Primary Ovarian Cancer Organoids for Predicting Clinical Response and Screening Effective Drugs

    We prepared organoids using the cancer tissue-originated spheroid method from 61 patients with ovarian cancer. Chemosensitivity assays for paclitaxel and carboplatin were performed using the primary organoids from 50 patients who received the chemotherapy.
    [Human Cell]

    Abstract

    Performance Assessment and Economic Analysis of a Human Liver-Chip for Predictive Toxicology

    870 Liver-Chips were analyzed to determine their ability to predict drug-induced liver injury caused by small molecules identified as benchmarks by the Innovation and Quality consortium, who had published guidelines defining criteria for qualifying preclinical models.
    [Communications Medicine]

    Full Article
    GI Organoid Applications
    REVIEWS

    Microglia-Containing Human Brain Organoids for the Study of Brain Development and Pathology

    Scientists review the current methods used to generate microglia-containing human brain organoids (MC-HBOs) and provide opinions on the use of MC-HBOs for disease modeling and functional studies.
    [Molecular Psychiatry]

    Full Article

    Engineered Organoids in Oral and Maxillofacial Regeneration

    The authors summarize the recent progress of novel approaches to engineering oral and maxillofacial organoids. They introduce the necessary components and their roles in forming oral and maxillofacial organoids.
    [iScience]

    AbstractGraphical Abstract
    INDUSTRY AND POLICY NEWS

    Crown Bioscience and ERS Genomics Announce Global CRISPR/Cas9 Licensing Agreement for Genome Editing Patents

    Crown Bioscience, Inc. and ERS Genomics Ltd. have signed a global license agreement for access to the foundational CRISPR/Cas9 patent portfolio held by ERS, which provides the company full license to operate globally using CRISPR/Cas9 for gene editing.
    [ERS Genomics Limited]

    Press Release
    FEATURED EVENT

    Organoids as Models of Development and Disease, and Their Impact on Drug Discovery

    February 5 – 8, 2023
    Keystone, Colorado, United States

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Position – Nervous Organoids & Biomimetic Nanomaterials 3D Cultures

    Center for Nanomedicine and Tissue Engineering – Milan, Italy

    PhD Positions – Biomedical Sciences

    Max Delbrück Center for Molecular Medicine – Berlin-Buch, Germany

    Animal Technician – Regenerative Immunology

    Lund University – Lund, Sweden

    Postdoctoral Researcher – Microtechnologies for Organoids

    Roche – Basel, Switzerland

    Research Associate – Epithelial Stem Cell Biology

    University of Cambridge – Cambridge, England, United Kingdom

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2
    STEMCELL Organoids Twitter