 | | Vol. 4.00 – 5 January, 2023 |
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| Investigators showed that subjecting organoids to fluid shear stress in a polycystic kidney disease-on-a-chip microphysiological system promoted cyst expansion via an absorptive rather than a secretory pathway.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers employed an in vitro, rabies virus-based, monosynaptic retrograde tracing assay to identify de novo synaptic connections among early retinal cell types following retinal organoid dissociation.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| Using an established human cerebral organoid model, scientists demonstrated that Di-(2-ethylhexyl) phthalate exposure markedly suppressed cell proliferation and increased apoptosis, thus impairing the morphogenesis of the human cerebral cortex.
[Science of The Total Environment] |
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| Polyploid giant cancer cells underwent restitution multipolar endomitosis, nuclear fragmentation, and micronuclei formation to increase nuclear contents and heterogeneity.
[Oncogene] |
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| Scientists developed cochlear organoids with functional peripheral auditory circuity in a staging three-dimensional co-culture system by initially reprogramming cochlear progenitor cells with increased proliferative potency that could be long-term expanded.
[Stem Cell Reports] |
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| Using intestinal metastatic tumor-derived organoids carrying Apc, Kras, Tgfbr2, and Trp53 quadruple mutations, the authors showed that approximately 30% of subclones of the organoids showed loss of metastatic ability to the liver.
[Cancer Science] |
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| Investigators presented the fabrication and characterization of isogenic scaffold-free cardiac organoids derived from hiPSCs formed under a supplement-deprivation regimen
[Acs Biomaterials Science & Engineering] |
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| A gut-on-a-chip integrated with transepithelial electrical resistance sensors and electrochemical sensors was proposed for dynamically simulating the formation of the physical intestinal barrier and monitoring the transport and absorption of Hg(II) in situ.
[Microsystems & Nanoengineering] |
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| Investigators described a multi-guide RNA CRISPR-Cas9 gene-editing protocol that efficiently achieved complete gene knockout in adult human colonic organoids.
[Star Protocols] |
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| Applying modular tools to organoids should lead to a deeper understanding of developmental principles, improved organoid models, and an enhanced capability to design tissues for regenerative purposes.
[Cell Stem Cell] |
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| Scientists summarize the culturing protocols and various applications of stem cell-derived organoids and propose insightful thoughts for engineering stem cells into organoids in view of the current shortcomings.
[Smart Medicine] |
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| STEMCELL Technologies announced that its President and CEO, Dr. Allen Eaves, has been appointed to the Order of Canada by Her Excellency the Right Honorable Mary Simon, the Governor General of Canada.
[STEMCELL Technologies] |
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| March 26 – 31, 2023
Ventura, California, United States |
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| | Stanford Medicine – Stanford, California, United States |
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| | Wellcome Sanger Institute – Cambridge, England, United Kingdom |
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| | Van Andel Research Institute – Grand Rapids, Michigan, United States |
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| | Columbia University – New York, New York, United States |
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| | Rutgers New Jersey Medical School – Newark, New York, United States |
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