 | | Vol. 4.02 – 12 January, 2023 |
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| Glucose elevation during differentiation was associated with DDX21 re-localization from the nucleolus to the nucleoplasm where DDX21 assembled into larger protein complexes containing RNA splicing factors.
[Cell] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers demonstrated that β5-integrin repressesed chemotherapy-induced canonical pyroptosis to confer cancer chemoresistance through ASAH2-driven sphingolipid metabolic reprogramming.
[Science Translational Medicine] |
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| Using intestinal organoids as a model of tissue regeneration, the authors showed that senescence-associated secretory phenotype factors released by senescent fibroblasts deregulated stem cell activity and differentiation and ultimately impaired crypt formation.
[Nature Communications] |
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| Investigators demonstrated that constructing in vivo osteo-organoids by implanting bone morphogenetic protein–2 (BMP-2)–loaded scaffolds into the internal muscle pocket near the femur of mice supported the growth and subsequent harvest of therapeutically useful cells.
[Science Advances] |
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| From single-cell sequencing analyses, scientists found that leader cells were heterogeneous and identified and isolated a keratin 14- and cadherin-3-positive subpopulation sufficient to lead collective migration.
[Developmental Cell] |
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| The authors explored the broad spectrum of human primordial germ cells-like cells (hPGCLCs) precursors and how different precursors impacted hPGCLC development.
[Cell Reports] |
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| Investigators showed that momuse primary epidermal organoids supported USA300 colonization and invasion, exhibiting swollen epithelial squamous cells with nuclear necrosis and secreting inflammatory factors such as IL-1β.
[Cell Death & Disease] |
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| Researchers revealed that injury caused by glossopharyngeal nerve transection triggered the remaining differentiated K8-positive taste receptor cells to dedifferentiate and acquire transient progenitor cell-like states during regeneration.
[Experimental & Molecular Medicine] |
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| Patient-derived organoids were generated from endoscopic biopsies of LAGAs prior to the initiation of chemotherapy and treated with the two chemotherapy regimens: FLOT and FOLFOX.
[Journal Of Gastrointestinal Surgery] |
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| The authors review the current developments involving microfluidic hydrogel-based scaffolds, promising structures for cartilage regeneration, ranging from hydrogels with microfluidic channels to hydrogels prepared by the microfluidic devices, that enable therapeutic delivery of cells, drugs, and growth factors.
[Advanced Materials] |
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| Investigators divide droplet microfluidic approaches for managing spheroids and organoids into three categories based on the droplet module format: liquid droplet, microparticle, and microcapsule.
[Lab on a Chip] |
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| BioGrad is to open the UK’s second largest biobank facility in Liverpool, as part of a £7.6m investment into a new headquarters at Wavertree Technology Park.
[News Medical] |
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| February 13 – 16, 2023
Breckenridge, Colorado, United States |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | Aspect Biosystems – Vancouver, British Columbia, Canada |
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| | Human Technopole – Milan, Italy |
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| | Van Andel Research Institute – Grand Rapids, Michigan, United States |
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| | The University of Texas MD Anderson Cancer Center – Houston, Texas, United States |
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