 | | Vol. 4.02 – 19 January, 2023 |
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| Researchers developed a bioengineering and machine learning framework that optimized organoid symmetry breaking by tuning their spatial coupling. This framework enabled reproducible generation of axially elongating organoids, each possessing a tail bud and neural tube.
[Cell] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators verified the recently suggested two subgroups of intrahepatic cholangiocarcinoma in the organoids model, and compared the characteristics between types.
[Nature Communications] |
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| The authors engineered an hiPSC co-culture system containing retinal organoids and microglia-like cells and tested their retinal invasion capacity and function.
[Journal Of Cellular And Molecular Medicine] |
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| Researchers performed an extensive meta-atlas characterization of cellular identities of the human eye, covering a wide range of developmental stages.
[Stem Cell Reports] |
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| The authors developed a novel, pump-less directional flow recirculating organ-on-a-chip platform that creates controlled unidirectional gravity-driven flow by a combination of a 3D-tilting system and an optimized microfluidic layout.
[Lab on a Chip] |
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| Investigators generated iPSCs from individuals with Down syndrome and euploid controls using urine-derived cells and examined their ability to differentiate into neurons and astrocytes grown in monolayer cultures, as well as into 3D cerebral organoids.
[Stem Cell Reviews And Reports] |
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| 3D brain organoid technology has promoted the study of human nervous system developmental diseases in recent years, providing a potential platform for elucidating the pathological mechanism of neurodevelopmental diseases.
[Cns Neuroscience & Therapeutics] |
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| Scientists used a human 3D self-assembling iPSC-derived model to characterize the effects of ischemia caused by oxygen-glucose deprivation.
[Journal Of Cerebral Blood Flow And Metabolism] |
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| Pancreatic tumor organoids were created from mouse pancreatic tumor tissues, and their microenvironment was compared to that of in vivo tumors using immunohistochemical and immunofluorescence staining.
[Frontiers In Oncology] |
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| New and more versatile chip designs are urgently needed to enable industrial applications and to support complex, 3D cell cultures.
[Nature Reviews Materials] |
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| Investigators summarize these emerging technologies and provide insights into how they can be utilized to fulfill the potential of stem cells.
[Trends In Biotechnology] |
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| As cancer immunotherapy has flourished and efforts to develop novel immunotherapies have increased, models that incorporate immune cells into organoid co-culture to recapitulate the complexity of the tumor microenvironment faithfully are in high demand.
[Annual Review Of Cancer Biology-Series] |
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| New medicines need not be tested in animals to receive FDA approval, according to legislation signed by President Joe Biden in late December 2022.
[ScienceInsider] |
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| April 17 – 19, 2023
Lund, Sweden |
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| | The University of Cambridge – Cambridge, England, United Kingdom |
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| | European Molecular Biology Laboratory – Barcelona, Spain |
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| | MRC National Institute for Medical Research – Cambridge, England, United Kingdom |
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| | Masaryk University – Brno, Czech Republic |
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| | The University of Southern Denmark – Odense, Denmark |
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