 | | Vol. 4.04 – 2 February, 2023 |
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| Researchers described a polymeric Toll-like receptor 7 agonist nanoparticle (TLR7-NP) adjuvant, which enhanced lymph node targeting, and led to persistent activation of immune cells and broad immune responses. They tested responses to this TLR7-NP using human tonsil organoids, and other methods.
[Nature Materials] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Glutathione peroxidase 4 was genetically altered in murine models for hepatocellular carcinoma and colorectal cancer (CRC) to analyze the effect of ferroptosis on tumor cells and the immune tumor microenvironment. Subcutaneously grown CRC organoids were utlilized, in addition to other methods.
[Gut] |
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| Scientists provided structural and functional evidence that human brain organoids successfully integrated with the adult rat visual system after transplantation into large injury cavities in the visual cortex.
[Cell Stem Cell] |
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| Using single-cell RNA and T cell receptor sequencing, researchers investigated the transcriptomic atlas of several types of cancer that were typically treated identically to squamous cell carcinoma. The promalignant properties of the structural cells were studied using organoids.
[Advanced Science] |
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| Scientists used a photoinduced hydrogel cross-link exchange reaction to spatiotemporally alter epithelial curvature and study how dynamic changes in curvature influence mechanotransduction pathways to instruct crypt morphogenesis in intestinal organoids.
[Science Advances] |
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| The authors applied recently developed tubuloid protocols to purify and propagate kidney epithelium from d7+18, post nephrogenesis, iPSC-derived organoids.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| RNA sequencing was conducted to generate a drug signature from retinoblastoma organoids, and the effects of drugs on cell cycle progression and proliferative tumor cone restriction were examined.
[Journal Of Experimental & Clinical Cancer Research] |
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| Scientists reported a mass spectrometry-based protocol to quantify neural tissue cell markers, cell surface lipids, and housekeeping proteins in a single cerebral organoid. Profiled traits probed the development of neural stem cells, radial glial cells, neurons, and astrocytes.
[Analytical Chemistry] |
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| Researchers developed cortical-blood vessel assembloids by fusing cortical organoid with blood vessel organoid to provide vasculature to brain organoids, and obtained the characteristics of increased expression of microglia and astrocytes in brain organoids.
[Cell Death Discovery] |
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| The athors tested whether commonly used trophoblastic cell lines, ACH-3P, HTR-8/SVneo, and SWAN-71 were capable of self-organizing into organoids and subsequent extravillous trophoblast differentiation.
[Placenta] |
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| Scientists describe the current trend from irreversible chip bonding to innovative, reversible fastening techniques in organ-on-a-chip devices.
[Nature Reviews Materials] |
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| The authors review current challenges in organ-on-a-chip engineering that often stem from the same challenges in the parent fields, such as stable vascularization and drug absorption.
[Trends in Biotechnology] |
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| Investigators summarize the common tumor types of patient-derived organoid biobanks and the necessary information for biobank construction, such as the number of organoids, morphology, success rate of culture and resuscitation, pathological types.
[Scientific Reports] |
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| A panel of experts joined a meeting of the US National Science Advisory Board of Biosecurity, discussing on issues such as how privately funded risky research would be regulated, the role of research institutions in identifying potentially dangerous research, and much more.
[Nature] |
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| April 23 – 26, 2023
Paris, France |
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| | The International Institute of Molecular and Cell Biology – Warsaw, Poland |
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| | Karolinska Institutet – Solna, Sweden |
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| | University of Copenhagen – Copenhagen, Denmark |
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| | The University of Cambridge – Cambridge, England, United Kingdom |
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| | European Molecular Biology Laboratory – Barcelona, Spain |
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