 | | Vol. 4.05 – 9 February, 2023 |
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| Aiming to better target and understand oncogenes to gastric stem cells and their behavior in the initial stages of gastric tumorigenesis, scientists used gastric cancer cell organoids that were genetically manipulated with CRISPR/Cas9 for functional studies, along with other methods.
[Gastroenterology] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Using multiple model systems of human brain tumor development such as cerebral glioblastoma organoids, and patient-derived tumor spheroids, scientists sensitized cancer cells to dihydroartemisinin using the clinically approved porphyrin enhancer and surgical fluorescence marker 5-aminolevulinic acid.
[EMBO Molecular Medicine] |
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| Investigators provided novel insights into how WFS1 deficiency affected synapse formation and function, and offered a strategy to treat wolfram syndrome.
[Molecular Psychiatry] |
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| The authors investigated the susceptibility and biological responses of the olfactory system to Zika virus infection using mouse models and human olfactory organoids derived from patient olfactory mucosa.
[Ebiomedicine] |
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| Researchers identified mutations in ATRX and/or DAXX genes in an extensive collection of colorectal cancer (CRC) samples, including 119 patient-derived organoids.
[Cell Death & Disease] |
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| Investigators developed a 3D-printed electrochemical multiwell plate to determine changes in 5-HT levels from intestinal organoids that were exposed to varying chemical components found in food.
[Acs Sensors] |
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| Researchers aimed to set up a model that preserved the phenotype of the patient-specific tissue using mature cerebral organoids, and developed a pipeline for subsequent analysis of co-cultured glioblastoma.
[Molecular Oncology] |
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| The authors injected postmortem spinal cord protein extracts individually from three non-Amyotrophic lateral sclerosis (ALS) or five sporadic ALS patients, containing pathogenic TDP-43 into the cerebral organoids to validate the templated propagation and spreading of TDP-43 pathology in human central nervous system tissue.
[PLOS Genetics] |
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| Scientists used intestinal organoids to test cystic fibrosis transmembrane conductance regulator (CFTR) increasing potential of a 1400-compound FDA-approved drug library in organoids from donors with W1282X/W1282X CFTR nonsense mutations.
[Erj Open Research] |
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| The authors discuss essential structure–function relationships of the central nervous system (CNS) and examine materials and design considerations, including composition, scale, complexity and maturation, of cell biology-based and engineering-based CNS models.
[Nature Reviews Bioengineering] |
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| Scientists describe organ-on-a-chip technology and provide examples of how it may be used for disease modeling and pharmacogenetic research.
[Trends In Genetics] |
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| A former behemoth U.K. government department has been split into new seperate science, energy, and trade ministries.
[Science Insider] |
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| March 31, 2023
Amsterdam, The Netherlands |
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| | STEMCELL Technologies, Inc. – Cambridge, England, United Kingdom |
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| | Weill Cornell Graduate School of Medical Sciences – New York, New York, United States |
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| | King’s College London – London, England, United Kingdom |
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| | The International Institute of Molecular and Cell Biology – Warsaw, Poland |
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| | University of Copenhagen – Copenhagen, Denmark |
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Cancer Stem Cell News
Cell Therapy News
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ESC & iPSC News
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Intestinal Cell News
Mammary Cell News
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