 | | Vol. 4.06 – 16 February, 2023 |
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| Two autophagy-related genes, myristoylated alanine rich protein kinase C substrate (MARCKS) and thioredoxin interacting protein (TXNIP), marked high-plasticity gastric cancer with poorer prognosis, and autophagy inhibitors induced apoptosis in patient-derived organoids.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors developed a machine-learning framework for comparative gene expression analysis of brains and organoids to identify conserved and specific developmental trajectories, as well as developmentally expressed genes and functions, especially at cellular resolution.
[Cell Reports Methods] |
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| Transplanted organoids were established from sulfomucin-enriched region into the injured recipient epithelium following dextran sulfate sodium-induced colitis and analyzed the engrafted epithelium in mouse model.
[Journal of Gastroenterology] |
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| Investigators demonstrated two different engineering approaches, the rotating cell culture system microgravity bioreactor and a newly designed microfluidic platform to improve harvestability, reproducibility, and the survival of high-quality cerebral organoids and compare with those of traditional spinner and shaker systems.
[Communications Biology] |
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| The authors presented a microvasculature-on-chip model to investigate the singular effect of extracellular matrix stiffness and mechanical cyclic stretch on vascular development.
[iScience] |
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| Scientists measured mechanoinduced changes in intracellular Ca2+ concentration in tubules isolated from organoids cultured for 21-64 days, microperfused in vitro or affixed to the base of a specimen chamber, and loaded with fura-2 to measure Ca2+ concentration.
[American Journal Of Physiology-Cell Physiology] |
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| Researchers investigated miR-23b-3p function during receptivity. qPCR and in situ hybridization were used to investigate the expression and localization of miR-23b-3p in human endometrium, respectively.
[Reproduction] |
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| Using human intestinal mini-gut organoids, multiplex RNA FISH and single cell RNA sequencing, investigators were able to determine the intestinal cell type specific response to virus infection.
[Biophysical Journal] |
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| Scientists established bovine lung tissue decellularization for the first time via pursuing four different protocols and characterization of reconstituted decellularized lung extracellular matrix hydrogels for biochemical and mechanical properties.
[ACS Applied Bio Materials] |
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| The authors discuss how 3D cancer model systems are applied to deconstruct and engineer the tumor microenvironment, opening opportunities to model primary tumors, metastasis and responses to anticancer treatment.
[Nature Reviews Materials] |
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| To evaluate patients who will respond to a particular treatment, there is a need to develop in vitro model systems that replicate in vivo tumor status. Scientists discuss the challenges and opportunities for developing such systems to model head and neck tumor biology.
[British Journal Of Cancer] |
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| Xilis and The University of Texas MD Anderson Cancer Center announced a strategic collaboration to deploy Xilis’s proprietary MicroOrganoSphere™ technology in support of pre-clinical research to accelerate the development of novel cancer therapies.
[Xilis (Cision US, Inc.)] |
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| March 31, 2023
Amsterdam, The Netherlands |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| | STEMCELL Technologies, Inc. – Cambridge, England, United Kingdom |
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| | Paracelsus Medical University – Salzburg, Austria |
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| | King’s College London – London, England, United Kingdom |
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| | The International Institute of Molecular and Cell Biology – Warsaw, Poland |
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Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
