 | | Vol. 4.07 - 23 February, 2023 |
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| The authors used human fetal hepatocyte organoids to model the first stage of nonalcoholic fatty liver disease, steatosis, representing three different triggers: free fatty acid loading, interindividual genetic variability, and monogenic lipid disorders.
[Nature Biotechnology] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Using 3D immune-stem cell organoids, single-cell analysis of human emphysema lungs, and studies in murine models, researchers investigated aberrant tissue-immune interactions in emphysema.
[Immunity] |
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| Alpha kinase 3 (ALPK3) deficiency impaired contractility both in human cardiac organoids and in the hearts of mice harboring a pathogenic truncating Alpk3 variant.
[Nature Cardiovascular Research] |
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| The authors generated hiPSC lines using peripheral blood mononuclear cells from two male Fabry disease patients with different types of GLA mutations, and then generated kidney organoids using wild-type hiPSC and mutant hiPSCs.
[Journal Of Translational Medicine] |
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| Scientists established patient-derived organoid lines from ten patients with breast cancer and performed single-cell transcriptomic analysis.
[Breast Cancer Research] |
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| Researchers biobanked airway organoids by preserving stem cell function, and then optimized viral infection with H1N1/PR8 and comprehensively characterized epithelial responses to SARS-CoV-2 infection in phenotypically stable airway organoids from 20 different subjects.
[Stem Cell Reports] |
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| Investigators presented a 3D iPSC-derived paradigm—mature brain organoids—composed of cortical-like-astrocytes and neurons, and used these organoids to model TAR-DNA binding protein 43-related pathology.
[Stem Cell Reports] |
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| Researchers identified a combination of triple transcription factors capable of efficiently reprogramming mouse fibroblasts into self-organized and networked induced autonomic ganglion organoids, and characterized them by immunostaining, qRT-PCR, patch-clamping, and scRNA-seq approaches.
[iScience] |
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| Scientists demonstrated that by mixing surface enhanced Raman scattering microsensors (SERS-MS) into the extracellular matrix (ECM) of airway organoid cultures, the probes could be engulfed by expanding organoids, and reported on local pH in the organoid lumen and ECM.
[Chemical Communications] |
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| Investigators highlight the use of organoids and organs-on-chips as complementary reference tools in treating colorectal cancer from the perspective of clinical efficacy predictability.
[Cell Death & Disease] |
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| The authors review how the implementation of 3D organoid technology into tumor microenvironment-modeling platforms might facilitate the exploration of macrophage-targeted therapies in non-small cell lung cancer immunotherapeutic research.
[Elife] |
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| The money had been earmarked for UK involvement in the EU's Horizon Europe €100bn research programme. The funds have not been spent because the UK's association with the programme has been held up by the dispute over the Northern Ireland Protocol.
[BBC News] |
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| March 26 - 29, 2023
Snowbird, Utah, United States |
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| | The Institute for Tumor Biology and Experimental Therapy, Georg-Speyer-Haus - Frankfurt, Germany |
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| | St. Jude Children's Research Hospital - Memphis, Tennessee, United States |
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| | STEMCELL Technologies, Inc. - Cambridge, England, United Kingdom |
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| | Weill Cornell Graduate School of Medical Sciences - New York, New York, United States |
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| | The International Institute of Molecular and Cell Biology - Warsaw, Poland |
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