 | | Vol. 4.08 – 2 March, 2023 |
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| Organoids, patient-derived xenografts, and spontaneous pancreatic cancer mice were used to examine the efficacy of the combination of a ubiquitin-conjugating enzyme E2T (UBE2T) inhibitor and gemcitabine.
[Gastroenterology] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists used a lineage-traced sporadic model of pancreatic cancer to generate a murine organoid biobank from primary and secondary tumors, including sublines that underwent partial epithelial-mesenchymal transition (EMT) and complete EMT.
[Cell Death & Differentiation] |
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| A modified chemical resetting protocol allowed for the fast and efficient conversion of conventional PSCs into trophoblast stem cells (TSCs), entailing shutdown of pluripotency genes and full activation of the trophoblast master regulators, without induction of amnion markers.
[EMBO Reports] |
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| As determined via immunostaining and confocal microscopy, iPSCs generated using the Cell X platform gave rise to retinal organoids that were indistinguishable from organoids derived from manually generated iPSCs.
[Journal Of Translational Medicine] |
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| Scientists investigated the role of intestinal synthesis of glucocorticoids in the tumor development during inflammation-induced mouse model of colorectal cancer, using transplantation of glucocorticoid synthesis-proficient colorectal tumor organoids into immunocompetent recipient mice, and other methods.
[Molecular Oncology] |
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| Using ventral telencephalic organoids derived from human iPSCs, researchers investigated the effect of 16p11.2 microdeletion on organoid size, progenitor proliferation and organization into neural rosettes, ganglionic eminence marker expression at early developmental timepoints, and more.
[Development] |
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| Investigators transplanted lung cancer cell lines and cell line-derived organoid into a chorioallantoic membrane to investigate angiogenesis and invasion.
[Cancer Cell International] |
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| Single-cell transcriptomics of 30 and 90 days differentiated cerebral organoids deficient in circFAT3 showed a loss of telencephalic radial glial cells and mature cortical neurons, respectively.
[Molecular Neurobiology] |
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| In in vitro and ex vivo 3D organoid models, inflammation inhibitor-specific blocked ER–/PR+ tumor proliferation and migration.
[Breast Cancer] |
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| The authors highlight emerging techniques that further extend the applications of ultrasound imaging, including for ultrafast imaging of biomaterials and engineered tissues in vivo, and functional monitoring of stem cells, organoids, and organ-on-a-chip systems in vitro.
[Biomaterials] |
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| Scientists outline various gut-on-a-chip designs, particularly focusing on different configurations used to coculture the microbiome and various human intestinal cells.
[APL Bioengineering] |
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| A transplant of stem cell-derived nerve cells was administered to a person with Parkinson’s at Skåne University Hospital, Sweden. The product has been developed by Lund University and it is now being tested in patients for the first time.
[Lund University] |
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| April 23 – 28, 2023
Cancun, Mexico |
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| | Rutgers Biomedical and Health Sciences – New Brunswick, New Jersey, United States |
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| | Karolinska Institutet – Solna, Sweden |
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| | The Institute for Tumor Biology and Experimental Therapy, Georg-Speyer-Haus – Frankfurt, Germany |
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| | STEMCELL Technologies, Inc. – Cambridge, England, United Kingdom |
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| | The International Institute of Molecular and Cell Biology – Warsaw, Poland |
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