 | | Vol. 4.09 – 9 March, 2023 |
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| Using whole-genome analysis of 37 patients with metastatic colorectal cancer (mCRC) treated with the chemotherapy trifluridine/tipiracil, researchers identified KRAS codon G12 mutations as a potential biomarker of resistance.
[Nature Medicine] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Functionally, ACOX1 depletion promoted colorectal cancer cell proliferation in vitro and colorectal tumorigenesis in mouse models, whereas acyl-CoA oxidase 1 (ACOX1) overexpression inhibited patient-derived xenograft growth.
[Cell Discovery] |
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| Mechanistically, intratissue Ruminococcus gnavus and Blautia producta degraded lyso-glycerophospholipids that inhibited CD8+ T cell activity and maintained the immune surveillance function of CD8+ T cells.
[Cell Host & Microbe] |
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| Using an experimental pipeline enabling pancreatic ductal adenocarcinoma organoid isolation and collection based on invasive phenotype, researchers assessed the transcriptomic programs associated with invasion in their organoid model.
[Journal Of Clinical Investigation] |
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| Investigators established a human three-dimensional in vitro model of maternal immune activation by treating iPSC-derived dorsal forebrain organoids with a constitutively active form of IL-6, Hyper-IL-6.
[Molecular Psychiatry] |
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| Scientists used a specific adenine base editing approach, which was delivered as mRNA. This approach was validated in patient-derived rectal organoids and bronchial epithelial cells showing sufficient gene correction to recover the cystic fibrosis transmembrane conductance regulator (CFTR) function.
[Molecular Therapy] |
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| To build a preclinical platform that covered the broad disease spectrum of human lung cancer, the authors obtained lung cancer specimens from multiple sources, including sputum and circulating tumor cells, and generated a living biobank consisting of 43 lines of patient-derived lung cancer organoids.
[Cell Reports] |
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| Researchers investigated expression of Notch3 in human breast cancer samples and effects of its loss in mice. Notch3 expression was very weak in breast cancer cells and was associated with good patient prognosis.
[Cell Death & Disease] |
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| Ainsliadimer A inhibited the proliferation and induced apoptosis of colorectal cancer cells. Additionally, it inhibited tumor growth in mice and the growth of tumor organoid models.
[Cell Chemical Biology] |
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| Investigators describe recent advances in base editing of mitochondrial DNA and the generation of 3D organoids from patient-derived human-iPSCs, and the potential for these new technologies in the context of studying mitochondrial DNA diseases.
[EMBO Reports] |
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| The authors review current advances in the development of intestinal organoids that have led to a better recapitulation of the complexity, physiology, morphology, function, and microenvironment of the intestine.
[Life Sciences] |
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| Dr. Takebe received the NYSCF – Robertson Investigator Award for his pioneering work in understanding liver disease by creating liver organoids from stem cells. With these liver organoids, Dr. Takebe aims to understand exactly how liver diseases form and progress, as well as develop strategies to better treat them.
[NYSCF] |
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| New funding has been awarded to Dr. Joana Neves, to further develop a human organoid model to generate mucosal immune cell populations. The funding was awarded as part of a £4.7m investment from several institutions to support the next generation of non-animal technologies.
[King’s College London] |
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| Dr. Elfie Rödel discusses selecting appropriate 3D cultures for different applications, the challenges of establishing and using these models, and shares her best practice tips for working with these exciting new cultures.
[RegMedNet] |
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| April 17 – 19, 2023
Freiburg im Breisgau, Germany |
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| | University of Cambridge – Cambridge, England, United Kingdom |
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| | University Hospital Duesseldorf – Düsseldorf, Germany |
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| | University of Houston – Houston, Texas, United States |
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| | Rutgers Biomedical and Health Sciences – New Brunswick, New Jersey, United States |
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| | STEMCELL Technologies, Inc. – Cambridge, England, United Kingdom |
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Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
