Organoid News Volume 4.10 | Mar 16 2023

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    Laurisa Dohm
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    2023-03-16 | ON 4.10


    Organoid News by STEMCELL Technologies
    Vol. 4.10 – 16 March, 2023
    TOP STORY

    Combinatorial Treatment Rescues Tumor-Microenvironment-Mediated Attenuation of MALT1 Inhibitors in B-Cell Lymphomas

    The authors used >1,100 diffuse large B cell lymphoma patient samples to determine immune and extracellular matrix cues in the lymphoid tumor microenvironment, and built representative synthetic-hydrogel-based B-cell-lymphoma organoids accordingly.
    [Nature Materials]

    Abstract
    How to prioritize and manage your research projects
    PUBLICATIONSRanked by the impact factor of the journal

    Mechanosensitive Extrusion of Enterovirus A71-Infected Cells From Colonic Organoids

    Investigators reported that entire Enterovirus A71-infected cells were specifically extruded from the apical surface of differentiated human colon organoids, as observed by confocal microscopy.
    [Nature Microbiology]

    Full Article

    A Multi-Organoid Platform Identifies CIART as a Key Factor for SARS-CoV-2 Infection

    The authors systematically examined changes in transcript profiles caused by SARS-CoV-2 infection at different multiplicities of infection for lung airway organoids, lung alveolar organoids, and cardiomyocytes, and identified several genes that were generally implicated in controlling SARS-CoV-2 infection.
    [Nature Cell Biology]

    Full Article

    Synthetic Enforcement of STING Signaling in Cancer Cells Appropriates the Immune Microenvironment for Checkpoint Inhibitor Therapy

    Researchers found in human and murine colorectal cancer (CRC) models that the superior antitumor immune response of mismatch repair–deficient CRC required tumor cell–intrinsic activation of cGAS-STING signaling triggered by genomic instability.
    [Science Advances]

    Full Article

    Mechanical Stimuli-Induced CCL2 Restores Adult Mouse Cells to Regenerate Hair Follicles

    Scientists observed that the skin cells harvested from post-hair plucking day three had the best self-organizing ability during skin organoid culture and had the highest hair regeneration upon transplantation.
    [Molecular Therapy – Nucleic Acids]

    AbstractGraphical Abstract

    The SMARCA4R1157WM Mutation Facilitates Chromatin Remodeling and Confers PRMT1/SMARCA4 Inhibitors Sensitivity in Colorectal Cancer

    Investigators showed that the SMARCA4R1157WM mutant reinforced the transcriptional expression of EGFR and TNS4 to promote the proliferation of colorectal cancer cells and patient-derived tumor organoids.
    [NPJ Precision Oncology]

    Full Article

    Towards Automatization of Organoid Analysis: A Deep Learning Approach to Localize and Quantify Organoid Images

    Researchers developed a free e-Science service, named OrganelX, for localization and quantification of organoid size based on deep learning methods. The ability of the system was tested on murine liver organoids, and the data were made publicly available.
    [Computer Methods And Programs In Biomedicine]

    Full Article

    Loss of LGR5 through Therapy-Induced Downregulation or Gene Ablation Is Associated with Resistance and Enhanced MET-STAT3 Signaling in Colorectal Cancer Cells

    Combination treatment of MET-STAT3 inhibitors with irinotecan or antibody-drug conjugates substantiated synergistic effects in colorectal cancer cells and tumor organoids.
    [Molecular Cancer Therapeutics]

    Abstract

    Protocol to Engineer Apical-Out Airway Organoids Using Suspension Culture of Human Airway Basal Stem Cell Aggregates

    Scientists present a protocol to engineer apical-out airway organoids directly from human airway basal stem cells (hABSCs), using suspension culture of hABSC aggregates on a cell-repellent surface.
    [Star Protocols]

    Full ArticleGraphical Abstract
    Virtual Conference Exhibition: Pluripotent Stem Cells
    REVIEWS

    Functional Precision Oncology Using Patient-Derived Assays: Bridging Genotype and Phenotype

    The authors discuss several examples of personalized functional assays involving tumor organoids, spheroids, and explants and their potential to predict treatment responses and drug-induced toxicities in individual patients.
    [Nature Reviews Clinical Oncology]

    Abstract

    Middle-Out Methods for Spatiotemporal Tissue Engineering of Organoids

    Scientists introduce an emerging framework, which they term middle-out strategies, that relies on existing design principles and combines top-down design of defined synthetic matrices that support proliferation and self-organization with bottom-up modular engineered intervention to limit the degrees of freedom in the dynamic process of organoid morphogenesis.
    [Nature Reviews Bioengineering]

    Abstract
    INDUSTRY AND POLICY NEWS

    3.8 Million Euros for Endowed Professorship and Laboratory

    The funding will be used for an endowed Technical Univerysity of Munich professorship for AI-supported organoid development, and the highly specialized Heinz Nixdorf Laboratory for Organoid System Analytics.
    [Technical University of Munich]

    Press Release
    FEATURED EVENT

    4th Summit on Stem Cell Derived Beta Cells

    April 24 – 25, 2023
    Cambridge, Massachusetts, United States

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Researcher – Immune Competent Tumor-on-Chip Model

    Oslo University Hospital – Oslo, Norway

    Research Assistant – Epithelial Biology and Dermatology

    Stanford University School of Medicine – Stanford, California, United States

    Postdoctoral Researcher – Whipworm Infection

    University of Cambridge – Cambridge, England, United Kingdom

    Senior Scientist – Preclinical Immunotherapy of Cancer

    University Hospital Duesseldorf – Düsseldorf, Germany

    Research Assistant Professor – Cell Molecular Biology

    University of Houston – Houston, Texas, United States

    > See All Jobs

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