 | | Vol. 4.11 – 23 March, 2023 |
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| Physiologically, liver acute lipid accumulation induced the phosphorylation of eukaryotic translation initiation factor 2, which consequently attenuated Mier1 translation. Mesoderm induction early response 1 (MIER1) downregulation then promoted cell cycle gene expression and regeneration through chromatin remodeling.
[Nature Communications] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists cultured bone marrow mesenchymal stem cells in a 3D chip and implanted them into rabbit defect models of low-oxygen cartilage and high-oxygen calvaria bone in order to simulate site-specific skeletogenesis from hypoxic bone marrow.
[Science Advances] |
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| Investigators reported a novel optogenetic regulatory system for insulin secretion in human pluripotent stem cell-derived pancreatic islet-like organoids using monster-opto-Stromal interaction molecule 1.
[Molecular Therapy] |
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| Molecular simulation was conducted to evaluate ensartinib c-MET interaction, and cell lines, patient-derived organoids, and xenograft models were used to test the effectiveness of ensartinib.
[Cancer Letters] |
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| Scientists differentiated retina and anterior neural fold homeobox(RAX)::VENUS knockin hESCs into hypothalamic organoids and sorted RAX+ cells from mature organoids. The isolated RAX+ cells formed neurospheres and exhibited self-renewal and multipotency.
[Stem Cell Reports] |
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| Researchers showed the generation of thymic epithelial cells in vitro in isogenic stem cell-derived thymic organoids, consisting of thymic epithelial progenitors, hematopoietic progenitor cells, and mesenchymal cells, differentiated from the same hPSC line.
[Stem Cell Reports] |
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| Patient-derived organoid models were constructed to assess the therapeutic efficiency of Oxypalmatine in breast cancer.
[Phytomedicine] |
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| Investigators presented a workflow for culturing organoids with morphogen gradient using a CUBE culture device, followed by sectioning samples with the CUBE to retain information on gradient direction.
[Communications Biology] |
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| Researchers used airway organoids to screen a chemical library of autophagic modulators to identify compounds that could potentially be used to fight against infections by a broad range of coronaviruses.
[Molecular Pharmaceutics] |
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| The authors review recent developments in in vitro neuromuscular junction (NMJ) models with 2D or 3D cultures, from organ-on-a-chip and organoids, to biohybrid robotics. They also introduce related derivative techniques for functional analysis of the NMJ.
[Advanced Materials] |
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| The University of Sydney will lead the establishment of the NSW Organoid Innovation Centre, a new multi-institution facility that will apply the latest stem-cell techniques to accelerate drug discovery and design.
[The University of Sydney] |
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| April 25 – 26, 2023
London, England, United Kingdom |
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| | Oslo University Hospital – Oslo, Norway |
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| | Boston Children’s Hospital – Boston, Massachusetts, United States |
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| | Oslo University Hospital – Oslo, Norway |
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| | Ariel University – Ariel, West Bank |
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| | Stanford University School of Medicine – Stanford, California, United States |
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