 | | Vol. 4.12 – 30 March, 2023 |
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| Scientists used a cellular map to infer the possible transcription factors mediating extravillous trophoblast cells (EVT) invasion, and showed that they are preserved in in vitro models of EVT differentiation from primary trophoblast organoids, and trophoblast stem cells.
[Nature] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| A novel patient-derived meningioma organoid model was established to characterize a unique initiating cell subpopulation in high-grade meningiomas.
[Advanced Science] |
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| Researchers revealed that the competence for the future cardiac fate of hESCs was preset in pluripotency by a specialized mRNA translation circuit controlled by RNA binding protein with multiple splicing (RBPMS).
[Science Advances] |
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| The authors presented a multi-scale imaging approach that traversed millimeter-scale live-cell light microscopy to nanometer-scale volume electron microscopy by performing 3D cell cultures in a single carrier that was amenable to all imaging steps.
[Developmental Cell] |
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| Investigators introduced a novel Polydimethylsiloxane (PDMS) microwell platform containing 62 V-bottom micro-cavities for retinal organoids differentiation from hiPSCs.
[Biofabrication] |
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| Scientists used human telencephalic brain organoids grown using a dual reporter cell line to isolate neural progenitors and neurons and performed cell class and developmental stage-specific transcriptome and proteome analysis.
[Elife] |
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| 3D organoid-based models (pulmospheres) were developed from the lung biopsy tissues of 23 patients with interstitial lung diseases, and compared to normal control pulmospheres obtained from nine explant lung donor samples.
[Respiratory Research] |
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| Biliary organoids were generated from human livers and grown embedded into Culturex Basement Membrane Extract as spheroids around an internal lumen.
[Hepatology Communications] |
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| Using hESC-derived retinal organoids, scientists investigated the transcriptomic profiles of CD29+/CD44+ cells isolated from early and late stages of organoid development.
[Scientific Reports] |
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| The authors review current state-of-the-art multi-omics technologies, such as single-cell transcriptomics and chromatin accessibility assays, employed to study organoids as a model for development and a platform for precision medicine.
[Biology Direct] |
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| In draft guidance, the FDA outlined plans to move away from single-arm studies and instead favor randomized controlled trials that can potentially serve as the basis for both accelerated and full approval.
[Fierce Biotech] |
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| April 25 – 26, 2023
Boston, Massachusetts, United States |
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| | King’s College London – London, England, United Kingdom |
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| | Institute of Cancer Research – London, England, United Kingdom |
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| | VIB-UAntwerp Center of Molecular Neurology – Antwerp, Belgium |
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| | Pfizer, Inc.- Cambridge, Massachusetts, United States |
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| | Oslo University Hospital – Oslo, Norway |
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