 | | Vol. 4.13 – 6 April, 2023 |
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| Scientists generated self-organizing hiPSC-derived epicardioids that displayed retinoic acid-dependent morphological, molecular, and functional patterning of the epicardium and myocardium typical of the left ventricular wall.
[Nature Biotechnology] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers reported a method for converting hESCs into ventral thalamic organoids with transcriptionally diverse nuclei identities.
[Cell Stem Cell] |
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| The authors employed global proteomic and single-cell genomic approaches in stable cell lines as well as iPSC-derived neurons and midbrain organoids to dissect the mechanisms underlying β-glucocerebrosidase-related neurodegeneration.
[Nature Communications] |
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| CD70 blocking reverted regulatory T cell-mediated suppression and thus reinvigorated CD8+ T-cell immunity. Anti-CD70+ anti-PD-1 therapy was evaluated in xenograft-derived organoids and humanized mice, exhibiting an improved tumor-killing efficacy.
[Nature Communications] |
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| Harmine was identified as a hit compound based on phenotypic screening of a 2D assay and patient-derived organoid model that was established from a patient with multiple drug resistance and breast metastases.
[Cancer Letters] |
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| Investigators described the establishment of atypical teratoid/rhabdoid tumor (ATRT) tumoroid models from two subgroups, and demonstrated that ATRT tumoroids retained subgroup-specific epigenetic and gene expression profiles.
[Oncogene] |
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| To identify drug candidates to maintain photoreceptor survival, scientists performed an unbiased, high-throughput screening of over 6,000 bioactive small molecules using retinal organoids differentiated from iPSCs of rd16 mouse, which was a model of Leber congenital amaurosis type 10.
[Elife] |
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| The authors developed an approach to induce hair peg-like sprouting in organoid cultures composed of epithelial and mesenchymal cells.
[Scientific Reports] |
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| Researchers studied induced hyperexcitability in human cerebral cortical organoids – setting the groundwork for neonatal seizure modelling – using electrophysiological techniques and pharmacological manipulations.
[Heliyon] |
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| The authors depict the possibility of evaluating changes related to both Alzheimer’s and Parkinson’s disease in retinal organoids obtained from potential patients long before the onset of the disease, constituting a valuable tool in early diagnosis.
[Seminars In Cell & Developmental Biology] |
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| PathAI announced the launch of PathExploreâ„¢, the world’s first structured, standardized, and scalable panel of human interpretable features offering unprecedented resolution of the tumor microenvironment from H&E whole-slide images.
[PathAI (PR Newswire, Inc.)] |
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| April 30 – May 5, 2023
Barga, Italy |
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| | Ottawa Hospital Research Institute – Ottawa, Ontario, Canada |
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| | Medical University of South Carolina – Charleston, South Carolina, United States |
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| | King’s College London – London, England, United Kingdom |
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| | Institute of Cancer Research – London, England, United Kingdom |
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| | VIB-UAntwerp Center of Molecular Neurology – Antwerp, Belgium |
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