 | | Vol. 4.15 – 20 April, 2023 |
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| Using patient-derived organoid cultures from different bladder cancer stages and grades, integrative analysis of drug response profiles with matched genomic analyses were carried out to determine enrichment thresholds for candidate markers of therapy response and resistance.
[Nature Communications] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors established a human 3D in vitro model of maternal immune activation by treating induced pluripotent stem cell-derived dorsal forebrain organoids with a constitutively active form of interleukin (IL)-6, Hyper-IL-6.
[Molecular Psychiatry] |
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| Immunofluorescence, quantitative RT-PCR, Western blot, and ELISA were performed to explore the inflammation protective mechanism of tryptophan metabolites in wildtype and Nrf2-deficient mice undergoing intestinal ischemia/reperfusion, hypoxia-reoxygenation induced intestinal organoids.
[Journal Of Translational Medicine] |
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| The authors established tooth organoids from early-postnatal mouse molar and incisor, which were long-term expandable, expressed dental epithelium stem cell markers, and recapitulated key properties of the dental epithelium in a tooth-type-specific manner.
[Stem Cell Reports] |
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| Investigators described a novel neuro-mesodermal assembloid model that recapitulated aspects of peripheral nervous system development such as neural crest cell induction, migration, and sensory as well as sympathetic ganglion formation.
[Stem Cell Reports] |
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| Researchers enrolled 29 patients, including 24 with salivary gland cancers and 5 with benign tumors. Resected tumors were subjected to organoid and monolayer cultures, as well as whole-exome sequencing.
[iScience] |
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| Investigators developed a transwell system in which airway organoid–derived differentiated human lung epithelial cells were co-cultured with primary human lung microvascular endothelial cells.
[Life Science Alliance] |
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| Researchers established an accessible fluorescent whole-mount approach for nuclear and membrane staining to first provide an overview of the organoid histology, and investigated the potential of renal organoids to model responses to drug toxicity.
[Scientific Reports] |
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| The authors provide a prospective for standardized cultivation mode, automatic morphological evaluation, and drug sensitivity screening using high-throughput methods.
[Cancer Letters] |
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| The Farmer Family Foundation pledged an additional $5M to support work at Cincinnati Children’s to make promising lab-grown tissues ready for human transplantation.
[Cincinnati Children’s Hospital Medical Center] |
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| | The Human Technopole Foundation – Milan, Italy |
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| | The University of Chicago – Chicago, Illinois, United States |
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| | Institute of Cancer Research – London, England, United Kingdom |
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| | Medical University of South Carolina – Charleston, South Carolina, United States |
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| | VIB-UAntwerp Center of Molecular Neurology – Antwerp, Belgium |
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