 | | Vol. 4.16 – 27 April, 2023 |
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| Investigators reported that the splicing factor SRSF1 was highly expressed in pancreatitis, pancreatic ductal adenocarcinoma (PDAC) precursor lesions, and tumors. Increased SRSF1 was sufficient to induce pancreatitis and accelerate KRASG12D-mediated PDAC.
[Cancer Discovery] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists found that the lncRNA, DNA damage inducible transcript 4 antisense RNA1 (DDIT4-AS1), was highly expressed in triple-negative breast cancer cell lines and tissues due to H3K27 acetylation in the promoter region.
[Advanced Science] |
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| RAD51 and γH2AX nuclear foci were evaluated by immunofluorescence in high-grade serous ovarian cancer patient-derived cell lines, organoids, and formalin-fixed, paraffin-embedded tumor samples.
[Clinical Cancer Research] |
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| Scientists optimized an automation approach to engineer tumor-mimetic 3D microtissues in Scaffold-supported Platform for Organoid-based Tissues using a liquid handler and showed comparable within- and between-sample variation to standard manual manufacturing.
[Advanced Healthcare Materials] |
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| The authors found that hiPSCs cocultured with stromal cells as spheroids could grow in a stirred bioreactor and develop into yolk sac-like organoids without the addition of exogenous factors.
[Cell Reports Methods] |
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| Crumbs homolog 1 (CRB1) patient-derived PSC were differentiated into CRB1 retinal organoids that showed diminished expression of variant CRB1 protein observed by immunohistochemical analysis.
[Stem Cell Reports] |
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| Investigators described a high-throughput platform to generate self-organizing and commensurate human lung buds derived from hESCs cultured on micropatterned substrates.
[Stem Cell Reports] |
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| Researchers reported a novel non-involuting congenital hemangioma (NICH) organoid system construction and optimization process. Both HE and immunohistological staining exactly matched NICH tissue.
[Journal of Biological Engineering] |
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| Scientists extracted 12 candidate transcription factors to induce hepatocyte differentiation by comparing their gene expression in liver ductal organoids and liver tissues.
[Hepatology Communications] |
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| The authors focus on the role of organoids as a direct tissue repair modality in inflammatory bowel disease (IBD). They review the translational roadmap for the application of organoids and the need for this as a novel direction in IBD.
[Inflammatory Bowel Diseases] |
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| Investigators provide a comprehensive review of the literature on recent advances in iPSC-derived 3D brain organoid culturing and their utilization in modeling major neurotropic viral infections including HIV-1, HSV-1, JCV, ZIKV, CMV, and SARS-CoV2.
[Journal Of Neurovirology] |
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| Through the Special Call on research for post-pandemic recovery and the New Frontiers in Research Fund 2022 Exploration competition fund, 12 McGill researchers received funding for their projects, for a total investment of $3.2 million.
[McGill Reporter] |
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| May 4 – 7, 2023
Riviera Maya, Mexico |
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| | University of Texas MD Anderson Cancer Center – Houston, Texas, United States |
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| | The Human Technopole Foundation – Milan, Italy |
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| | Ottawa Hospital Research Institute – Ottawa, Ontario, Canada |
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| | Institute of Cancer Research – London, England, United Kingdom |
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Cancer Stem Cell News
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