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| Using intracranial brain recordings during lexical retrieval language tasks in awake humans together with site-specific tumor tissue biopsies and cell biology experiments, scientists found that gliomas remodel functional neural circuitry.
[Nature] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers described a protocol to differentiate cultured human gastric stem cells into pancreatic islet-like organoids containing gastric insulin-secreting cells that resembled β-cells in molecular hallmarks and function.
[Nature Cell Biology] |
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| Investigators generated a set of human hepatocyte organoid models engineered to reflect different genetic backgrounds as identified in fibrolamellar carcinoma (FLC) or FLC-like cases.
[Nature Communications] |
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| Researchers reported that androgen receptor signaling pathway was evidently activated in tumor-associated macrophages of prostate cancer both in mice and humans.
[Advanced Science] |
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| Using a glioblastoma cerebral organoid model, investigators profiled the chromatin accessibility of 28,040 single cells in five patient-derived glioma stem cell lines.
[Cancer Research] |
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| Scientists described a method that directed iPSC-derived sclerotome to chondroprogenitors in 3D pellet culture then to articular chondrocytes or, alternatively, along the growth plate cartilage pathway to become hypertrophic chondrocytes that could transition to osteoblasts.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| Researchers showed that vascular cells within human cardiac organoids enhanced their maturation, force of contraction, and utility in disease modeling.
[Cell Reports] |
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| Pseudo proximal tubule cells extracted from hiPSC-derived kidney organoids were combined and cultured with immortalized proximal tubule cells.
[Communications Biology] |
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| Combination treatment of mesenchymal epithelial transition (MET)-STAT3 inhibitors with irinotecan or antibody–drug conjugates substantiated synergistic effects in colorectal cancer cells and tumor organoids.
[Molecular Cancer Therapeutics] |
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| The authors provide an overview of the achievements and challenges in using hPSC-derived organoids to conduct relevant high-throughput, high-content screens, and drug evaluation.
[Cell Stem Cell] |
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| Tapping into exciting new advances in biology, medical and scientific knowledge, technology, and data science, the Institute of Human Biology is a cross-disciplinary endeavor bringing together academia and industry.
[Roche] |
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| The Icahn School of Medicine at Mount Sinai announced the creation of the Institute for Regenerative Medicine to foster innovative research into new pathways to cure a host of diseases from leukemia to Alzheimer’s disease, breast cancer, and airway diseases.
[Mount Sinai] |
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| May 23 – 25, 2023
Bar Harbor, Maine, United States & Virtual |
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| | Roche Institute of Translational Bioengineering (ITB) – Zurich, Switzerland |
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| | The University of Oklahoma Health Sciences Center – Oklahoma City, Oklahoma, United States |
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| | Novartis – Cambridge, Massachusetts, United States |
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| | VIB-KU Leuven Center for Cancer Biology – Leuven, Belgium |
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