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| Researchers generated multiplexed protein maps over a retinal organoid time course and primary adult human retinal tissue. They also generated a single-cell transcriptome and chromatin accessibility timecourse dataset and inferred a gene regulatory network underlying organoid development.
[Nature Biotechnology] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors developed an in vivo xenotransplantation approach that allowed for the study of functionally mature human microglia that operated within a physiologically relevant, vascularized immunocompetent human brain organoid model.
[Cell] |
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| In human pancreatic ductal adenocarcinoma (PDAC) cell lines and organoids, researchers demonstrated that histone deacetylase sirtuin 6 (SIRT6) loss both defined the basal PDAC subtype and led to reduced activating transcription factor 4 protein stability, and a nonfunctional integrated stress response.
[Science Translational Medicine] |
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| Pharmacological inhibition of USP7 during endocrine specification in human iPSC models of beta-cell differentiation decreased Neurogenin 3 (NGN3) expressing progenitor cell numbers and impaired beta cell differentiation.
[Nature Communications] |
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| Scientists established organoids from cryopreserved material, demonstrating the feasibility of using viably biobanked tissue for high-grade serous ovarian cancer organoid derivation.
[Developmental Cell] |
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| Using single-cell multiome and histone modification analysis, the authors reported more broadly open chromatin in organoid cell types compared to the human adult kidney.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| Researchers reported an in vitro model of the placental barrier, based on co-culture of trophoblasts and endothelial cells against a collagen extracellular matrix in a microfluidic platform.
[Acta Biomaterialia] |
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| Investigators transplanted human retinal organoid-derived cells into photoreceptor-deficient mice and conducted histology and single-cell RNA sequencing alongside time-matched cultured retinal organoids.
[Stem Cell Reports] |
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| Researchers analyzed a time course of transplanted human intestinal organoid (HIOs) histologically at two, four, six, and eight weeks post-transplantation, and demonstrated that HIO maturation closely resembled key stages of fetal human intestinal development.
[Development] |
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| Scientists highlighted some of the traditional preclinical models used in cancer drug testing and debated how next generation organoids are being used to replace not only animal models, but also some of the more elementary in vitro approaches, such as cell lines.
[Biochemical Pharmacology] |
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| Outside the Third International Summit on Human Genome Editing, protesters held banners that read “Stop designer babies” and “Never again to eugenics”, calling for a ban on human genome editing. It was a reminder of the ethical quandaries that embryo science and genome editing can present.
[Nature News] |
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| The Maryland Stem Cell Research Fund Commission has announced over $14.1 million in grant awards to promote innovative research that will strengthen and advance stem cell treatments and technologies in Maryland.
[TEDCO] |
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| June 14 – 17, 2023
Boston, Massachusetts, United States |
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| | Center for Disease Neurogenomics at the Icahn School of Medicine – Manhattan, New York, United States |
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| | Weill Cornell Medical College – New York, New York, United States |
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| | Roche Institute of Translational Bioengineering – Zurich, Switzerland |
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| | VIB-KU Leuven Center for Cancer Biology – Leuven, Belgium |
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