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| Scientists found SARS-CoV-2 virus-like particles (trVLP) suppressed cell apoptosis, but the trVLP lacking N protein did not. Further study verified that N protein repressed cell apoptosis in cultured cells, human lung organoids, and mice.
[Signal Transduction And Targeted Therapy] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Organoids were established from head and neck cancer patient tumor tissue and characterized using immunohistochemistry and DNA sequencing. Organoids were exposed to chemo- and radiotherapy and a panel of targeted agents, and organoid response was correlated with patient clinical response.
[Med] |
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| In this Phase II, single-center, open-label, non-comparative study, 90 patients with metastatic colorectal cancer following progression on or after standard therapy were enrolled. Patient-derived organoids and in vitro sensitivity testing were feasible in a cohort of metastatic colorectal cancer.
[Journal Of Experimental & Clinical Cancer Research] |
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| Scientists established a bio-bank of human pancreatic ductal adenocarcinoma (PDAC) organoid models, covering a representative range of PDAC tumor subtypes.
[Journal of Experimental & Clinical Cancer Research] |
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| To develop clinically relevant models of these mutational processes investigators derived 15 continuous high-grade serous ovarian carcinoma patient-derived organoids and characterized them using bulk transcriptomic, bulk genomic, single-cell genomic, and drug sensitivity assays.
[eLife] |
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| Scientists utilized human cortical organoid technology to probe how methadone impacts the earliest mechanisms of cortico-genesis and provided novel insight into the molecular underpinnings of methadone’s putative effect on cognitive and behavioral development.
[Translational Psychiatry] |
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| Researchers investigated three dimension (3D) culture of human stem cell-derived islet organoids, with 3D culture initiated at the pancreatic progenitor, endocrine progenitor, or immature β-cell stage.
[Biomaterials Science] |
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| Investigators first generated human cortical organoids from a single rosette to create more homogenous organoids. They then took advantage of a 3D co-culture system to encapsulate brain organoids with a thin layer of meningeal cells from the very early stages of cortical development.
[Scientific Reports] |
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| Using models of patient-derived xenograft (PDX) model, patient-derived organoids, and PDX-derived organoids for salivary duct carcinoma (SDC), researchers examined the therapeutic effect of human epidermal growth factor receptor 2 (HER2) blockade on HER2-positive SDC.
[Head And Neck-Journal For The Sciences And Specialties Of The Head And Neck] |
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| The authors discuss recent advancements in microfluidics, organ-on-a-chip, and human stem cell–derived models to study SARS-CoV-2 infection in the physiological organ microenvironment, together with their limitations.
[Circulation Research] |
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| Investigators discuss how prostate organoid technology is currently being used, the promising areas of future therapeutic applications, and the current obstacles to be overcome.
[Journal Of Clinical Investigation] |
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| LIfT BioSciences announced preclinical data demonstrating that its Immunomodulatory Alpha Neutrophil product showed potent killing of pancreatic cancer tumoroids.
[LIfT BioSciences] |
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| June 3 – 7, 2023
San Diego, California, United States |
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| | University of Antwerp – Antwerp, Belgium |
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| | Guangzhou Medical University – Guangdong, China |
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| | Centre for Oncology and Immunology – Hong Kong, Hong Kong |
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| | DFG Research Training Group – Berlin, Germany |
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| | Center for Disease Neurogenomics at the Icahn School of Medicine – Manhattan, New York, United States |
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