Organoid News Volume 4.20 | May 25 2023

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    Laurisa Dohm
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    2023-05-25 | ON 4.20


    Organoid News by STEMCELL Technologies
    Vol. 4.20 – 25 May, 2023
    TOP STORY

    Establishment of Gastrointestinal Assembloids to Study the Interplay between Epithelial Crypts and Their Mesenchymal Niche

    The authors established a colon assembloid system comprising the epithelium and diverse stromal cell subtypes.
    [Nature Communications]

    Full Article
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    PUBLICATIONSRanked by the impact factor of the journal

    Non–Cell-Autonomous Regulation of Interneuron Specification Mediated by Extracellular Vesicles

    Using ventral cerebral organoids and dorsoventral cerebral assembloids with mutations in the extracellular matrix gene LGALS3BP, scientists showed that extracellular vesicles released into the extracellular environment regulate the molecular differentiation of neurons.
    [Science Advances]

    Full Article

    Dual Inhibition of CDK12 and CDK13 Uncovers Actionable Vulnerabilities in Patient-Derived Ovarian Cancer Organoids

    Viability assays with high grade serous ovarian cancer cells and patient-derived organoids were performed to assess the efficacy of the CDK12/13 inhibitor, THZ531, as single agent or in combination with clinically relevant drugs.
    [Journal Of Experimental & Clinical Cancer Research]

    Full Article

    Single-Cell Transcriptomics of Human-Skin-Equivalent Organoids

    By combining differential gene expression, pseudotime analyses, and spatial localization, researchers reconstructed human-skin-equivalent organoid cultures keratinocyte differentiation trajectories that recapitulated known in vivo epidermal differentiation pathways.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Modeling Human Ectopic Pregnancies with Trophoblast and Vascular Organoids

    Scientists employed cell culture and organoid models to investigate the crosstalk between human trophoblast development and intravillous vascularization in the ruptured ectopic pregnancy condition.
    [Cell Reports]

    Full ArticleGraphical Abstract

    In Vitro Construction of Liver Organoids with Biomimetic Lobule Structure by a Multicellular 3D Bioprinting Strategy

    The authors provided a droplet-based and layer-by-layer 3D bioprinting strategy for in vitro construction of liver organoids with biomimetic lobule structure.
    [Cell Proliferation]

    Full Article

    RTK Signaling Promotes Epithelial Columnar Cell Shape and Apical Junction Maintenance in Human Lung Progenitor Cells

    Cell shape dynamics and fate are tightly coordinated during development, therefore investigators used an organoid system to identify signaling pathways that maintained the columnar shape of human lung tip progenitors.
    [Development]

    Abstract

    CRISPR-Cas9 Correction of a Nonsense Mutation in LCA5 Rescues Lebercilin Expression and Localisation in Human Retinal Organoids

    Researchers observed opsin and rhodopsin mislocalization to the outer nuclear layer in patient-derived but not in the gene-corrected or unrelated control organoids.
    [Molecular Therapy-Methods & Clinical Development]

    Full ArticleGraphical Abstract

    Differentiation and Single-Cell RNA-Seq Analyses of Human Pluripotent-Stem-Cell-Derived Renal Organoids

    Investigators presented a protocol for the maintenance and differentiation of human pluripotent stem cells into renal organoids.
    [Star Protocols]

    AbstractGraphical Abstract
    Organoids: Experts Talk Standardization at Nature Research Round Table
    REVIEWS

    Organoid Culture Development for Skeletal Systems

    Scientists examine current progress in the development of skeletal system organoid culture systems and provide cues for future research trajectory in the field by analyzing the current research status of skeletal stem cells, their microenvironmental factors and various potential organoid culture matrix candidates.
    [Tissue Engineering Part B-Reviews]

    Abstract

    Organoids: The Current Status and Biomedical Applications

    The authors focus on the applications of organoids in basic biology and clinical research, and also highlight their limitations and future perspectives.
    [MedComm]

    Full Article
    INDUSTRY AND POLICY NEWS

    Next&Bio, CSI Singapore to Co-Develop Cancer Organoid Precision Medicine

    Next&Bio, a company specializing in organoid-based precision medicine, signed a memorandum of understanding with the Cancer Science Institute of Singapore (CSI Singapore) to develop novel precision medicines using cancer organoids.
    [Korean Biomedical Review]

    News Article
    FEATURED EVENT

    Advanced Cell and Tissue Biomanufacturing

    June 25 – 30, 2023
    Newry, Maine, United States

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    JOB OPPORTUNITIES

    Postdoctoral Position – Machine Learning for Cancer Pharmacogenomics

    Human Technopole – Milan, Italy

    Postdoctoral Intramural Research Fellowship Position – Orthobunyaviruses

    National Institute of Allergy and Infectious Diseases – Hamilton, Montana, United States

    Postdoctoral Fellow – Tumor Microenvironment

    Centre for Oncology and Immunology – Hong Kong, Hong Kong

    Assistant/Associate Professor – Genome Editing and Therapeutics

    Center for Disease Neurogenomics at the Icahn School of Medicine – Manhattan, New York, United States

    Postdoctoral Fellow – Stem Cell and Regenerative Medicine

    Weill Cornell Medical College – New York, New York, United States

    > See All Jobs

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