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| The authors modeled occult preneoplasia by biallelic inactivation of TP53, a common early event in gastric cancer, in human gastric organoids.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Modulation of hydrogel characteristics over time and according to culture evolution is often not possible. These limitations were overcome using a hydrogel-in-hydrogel live bioprinting approach that enabled the dynamic fabrication of instructive hydrogel elements within pre-existing hydrogel-based organ-like cultures.
[Nature Communications] |
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| Scientists cultured human cerebral organoids derived from human pluripotent stem cells and transplanted them into the junction of the infarct core and the peri-infarct zone of NOD-SCID mice subjected to stroke.
[NPJ Regenerative Medicine] |
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| Researchers report two different methods for generating melanoma patient-derived organoids, one which was embedded in collagen gel, and the other which was inlaid in Matrigel.
[Ebiomedicine] |
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| Investigators detailed an advanced vascularized lung cancer model, which includes patient-derived lung cancer organoids, lung fibroblasts, and perfusable vessels using 3D bioprinting technology.
[Biofabrication] |
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| The authors presented a scalable method for high-throughput screening of cell-free DNA from cardiac organoids.
[Elife] |
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| IPSCs were generated from 15 patients aged 14-76 years old, differentiated into retinal organoids, and scored based on their retinal differentiation capacity.
[Stem Cells Translational Medicine] |
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| Researchers developed a model of the aberrant epithelial reprogramming observed in idiopathic pulmonary fibrosis using alveolar organoids derived from human-iPSCs stimulated with a cocktail of pro-fibrotic and inflammatory cytokines.
[Life Science Alliance] |
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| Investigators established murine malignant mesothelioma organoids from p53+/- or wild-type C57BL/6 strain by intraperitoneal injection either with crocidolite or carbon nanotube.
[BMC Cancer] |
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| The authors elaborate on different strategies to improve the vascularized human brain organoid microenvironment using microfluidic devices, while discussing the current obstacles and future directions in this field.
[Lab On A Chip] |
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| Scientists summarize recent advances in brain organoid technologies and their applications in brain development and diseases, including neurodevelopmental, neurodegenerative, psychiatric diseases, and brain tumors.
[Neuroscience Bulletin] |
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| The US National Institutes of Health (NIH) delivered a stern warning to two in-house clinical researchers who had broken an important rule. They had failed to submit the results of two clinical trials they had overseen to ClinicalTrials.gov, a database meant to inform the public about human studies and their results.
[Science] |
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| June 25 – 30, 2023
Newry, Maine, United States |
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| | Karolinska Institutet – Stockholm, Sweden |
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| | Institute of Cancer Research – London, England, United Kingdom |
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| | Human Technopole – Milan, Italy |
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| | Center for Disease Neurogenomics at the Icahn School of Medicine – Manhattan, New York, United States |
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| | Weill Cornell Medical College – New York, New York, United States |
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