 | | Vol. 4.24 – 22 June, 2023 |
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| Human-specific robustness to CDK2 and CCNE1 depletion persisted in neural progenitor cells and cerebral organoids, supporting the G1-phase length hypothesis as a potential evolutionary mechanism in human brain expansion.
[Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists observed distinct cellular composition and epithelial structural changes in Fibroadenomas (FAs). Addtionally, they developped an human expandable FA organoid system and observed that most organoids seemed to be resistant to tamoxifen.
[Nature Communications] |
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| Inhibition of piR-1742, a PIWI-interacting RNA, significantly reduced tumor growth in renal cell carcinoma xenograft and organoid models.
[Experimental & Molecular Medicine] |
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| The authors developped a new 3D in vitro tissue model of microglia-containing retinal organoids by co-culturing retinal organoids and hiPSC-derived macrophage precursor cells.
[Glia] |
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| Researchers constructed an orthotopic xenograft model using CD34+ human hematopoietic stem cell–based humanized NOD scid gamma mouse mice injected with luciferase-expressing pancreatic cancer cell lines AsPC1 and BxPC3.
[International Immunopharmacology] |
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| Investigators tested sensitivities to Wnt activation in human gastric corpus and antral organoids to determine whether progenitor cells had region-specific differences in Wnt responsiveness.
[American Journal Of Physiology-Gastrointestinal And Liver Physiology] |
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| To overcome the limitation of studying interactions between microbial components and host tissue, researchers developed porcine colonoid-derived monolayers cultured on both permeable transwell inserts and tissue culture-treated polystyrene plates.
[Tissue Barriers] |
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| Scientists used single-cell RNA sequencing technologies to elucidate the identity of cells within the human efferent ducts and compared them to caput epididymis cells.
[Andrology] |
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| Investigators verified whether the 3D in vitro culture of stem cells derived from the canine yolk sac was capable of developing intestinal organoids.
[Theriogenology] |
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| Scientists summarize the fundamental properties of extracellular matrices in vivo and critical strategies to design matrices for organoid culture.
[Bioactive Materials] |
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| The authors explore the recent advancements in hPSC- and organoid-based modeling, discuss present and future applications of the model to autism spectrum disorder research.
[Translational Psychiatry] |
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| Investigators discuss the challenges faced in organoid fields around robustness, accuracy, and reproducibility and highlight the need to improve standards applied to all organoid approaches.
[Stem Cell Reports] |
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| Surgeon Paolo Macchiarini, who was once hailed as a pioneer of stem cell medicine, was found guilty of gross assault against three of his patients and sentenced to two years and six months in prison by an appeals court in Stockholm.
[Science Insider] |
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| September 4 – 7, 2023
Surrey, England, United Kingdom |
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| | University College Dublin – Dublin, Leinster, Ireland |
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| | King’s College London – London, England, United Kingdom |
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| | King’s College London – London, England, United Kingdom |
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| | Malm̦ University РMalm̦, Sweden |
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| | Centre for Oncology and Immunology – Hong Kong, Hong Kong |
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Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
