Organoid News Volume 4.25 | Jun 29 2023

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    2023-06-29 | ON 4.25


    Organoid News by STEMCELL Technologies
    Vol. 4.25 – 29 June, 2023
    TOP STORY

    Schizophrenia-Associated NRXN1 Deletions Induce Developmental-Timing- and Cell-Type-Specific Vulnerabilities in Human Brain Organoids

    Investigators leveraged human pluripotent stem cell-derived forebrain organoid models carrying neurexin-1 (NRXN1) heterozygous deletions in isogenic and schizophrenia patient genetic backgrounds and conducted single-cell transcriptomic analysis over the course of brain organoid development.
    [Nature Communications]

    Full Article
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    PUBLICATIONSRanked by the impact factor of the journal

    Sulfated Polysaccharide Regulates the Homing of HSPCs in a BMP-2-Triggered In Vivo Osteo-Organoid

    Researchers demonstrated that targeting the homing signaling of hematopoietic stem/progenitor cells (HSPCs) elevated the proportions and biological functions of HSPCs in the in vivo osteo-organoid.
    [Advanced Science]

    Full Article

    Drug Repurposing Screening and Mechanism Analysis Based on Human Colorectal Cancer Organoids

    Scientists established human colorectal cancer (CRC) tumor-derived organoids and developed a robust organoid-based drug screening system to efficiently identify repurposed drugs for CRC.
    [Protein & Cell]

    AbstractGraphical Abstract

    Human Pancreatic Ductal Organoids with Controlled Polarity Provide a Novel Ex Vivo Tool to Study Epithelial Cell Physiology

    Investigators developed an advanced culturing method for human pancreatic organoids based on the removal of the extracellular matrix that induced an apical-to-basal polarity switch.
    [Cellular and Molecular Life Sciences]

    Full ArticleGraphical Abstract

    Organoid Models of Breathing Disorders Reveal Patterning Defect of Hindbrain Neurons Caused by PHOX2B-PARMs

    To understand how PHOX2B-polyalanine repeat mutations (PHOX2B-PARMs) alter the function of PHOX2B and perturb the formation of retrotrapezoid nucleus (RTN) neurons, researchers generated human brainstem organoids with RTN-like neurons from human pluripotent stem cells.
    [Stem Cell Reports]

    Full Article

    Human Prostate Organoid Generation and the Identification of Prostate Development Drivers Using Inductive Rodent Tissues

    Scientists showed that hiPSCs can be differentiated into prostate organoids using neonatal rat seminal vesicle mesenchyme in vitro. The organoids can be used to study prostate development or modified to study prostate cancer.
    [Development]

    Abstract

    Defining Developmental Trajectories of Prosensory Cells in Human Inner Ear Organoids at Single-Cell Resolution

    Investigators established a SOX2-2A-ntdTomato human embryonic stem cell line using CRISPR/Cas9, and performed single-cell RNA-sequencing analyses with SOX2-positive cells isolated from inner ear organoids at various time points.
    [Development]

    Full Article

    Light-Responsive MicroRNA Molecules in Human Retinal Organoids Are Differentially Regulated by Distinct Wavelengths of Light

    To better understand and characterize light-regulated microRNAs (miRNAs), the authors generated light-responsive human retinal organoids that expressed miRNA families and clusters typically found in the retina.
    [iScience]

    AbstractFull ArticleGraphical Abstract

    Suspended Hydrogel Culture as a Method to Scale Up Intestinal Organoids

    Researchers developed a method of culturing intestinal organoids within suspended basement membrane extract hydrogels of various geometries.
    [Scientific Reports]

    Full Article
    Watch the Webinar On-Demand: “Re-Creating Disease with Kidney Organoids and CRISPR-Cas9”
    REVIEWS

    Pushing the Boundaries of Brain Organoids to Study Alzheimer’s Disease

    Scientists highlight the versatile applications of different types of brain organoids to model Alzheimer’s disease pathogenesis, including amyloid-β and tau aggregation, neuroinflammation, myelin breakdown, vascular dysfunction, and other phenotypes.
    [Trends in Molecular Medicine]

    Full Article
    INDUSTRY AND POLICY NEWS

    Research Excellence Recognized with $12M Funding

    The Health Research Council of New Zealand has announced a total of $53.7 million in government funding for research into pressing health issues, including a trial to help New Zealanders quit vaping and a project to research Māori views on assisted dying.
    [University of Auckland]

    Press Release

    A Blow to Cancer Research in the UK As National Cancer Institute Closes Down

    The UK’s National Cancer Research Institute (NCRI) has begun winding down operations and working on identifying and securing assets. The NCRI reported that it was becoming increasingly “unsustainable” to continue to fund the charitable organization.
    [Clinical Trial Arena]

    Press Release
    FEATURED EVENT

    Unconventional and Emerging Experimental Organisms in Cell and Developmental Biology

    September 17 – 20, 2023
    Surrey, England, United Kingdom

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    JOB OPPORTUNITIES

    Research Fellow – Bile Acids in NAFLD and Insulin Resistance

    The National University of Singapore – Singapore, Singapore

    Staff Scientist – Virology

    Baylor College of Medicine – Houston, Texas, United States

    Assistant Professor – Biomanufacturing

    The University of British Columbia – Vancouver, British Columbia, Canada

    Lecturer – Bioengineering

    King’s College London – London, England, United Kingdom

    Postdoctoral Researchers – Molecular & Biophysical Aspects of Skin and Mucosa Barriers

    Malmö University – Malmö, Sweden

    > See All Jobs

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