Organoid News Volume 4.27 | Jul 13 2023

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    2023-07-13 | ON 4.27


    Organoid News by STEMCELL Technologies
    Vol. 4.27 – 13 July, 2023
    TOP STORY

    Dense 4D Nanoscale Reconstruction of Living Brain Tissue

    To solve challenges surrounding insufficient 3D resolution in the 3D reconstruction of living brain tissue, scientists developed an integrated optical/machine-learning technology, LIONESS, live information-optimized nanoscopy enabling saturated segmentation.
    [Nature Methods]

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    Generating Functional Multicellular Organoids from Human Placenta Villi

    Investigators developed a robust, reliable methodology for generating placenta villi organoids from early, late, or diseased pregnancies using air–liquid surface culture.
    [Advanced Science]

    Full Article

    An Organoid-Based CRISPR-Cas9 Screen for Regulators of Intestinal Epithelial Maturation and Cell Fate

    Using mouse fetal and adult small intestinal organoids, researchers uncovered transcriptional differences between the fetal and adult state and identified rare adult-like cells present in fetal organoids.
    [Science Advances]

    Full Article

    Embedded Bioprinting of Breast Tumor Cells and Organoids Using Low Concentration Collagen Based Bioinks

    Scientists produced embedded, bioprinted breast cancer cells and tumor organoid models using low concentration collagen I based bioinks.
    [Advanced Healthcare Materials]

    Abstract

    Sumoylated SnoN Interacts with HDAC1 and p300/CBP to Regulate EMT-Associated Phenotypes in Mammary Organoids

    Investigators found that sumoylation promoted the interaction of SnoN with the epigenetic regulators histone deacetylase 1 (HDAC1) and histone acetylase p300 in epithelial cells.
    [Cell Death & Disease]

    Full Article

    Activation of α7nAChR in AT2 Promotes Alveolar Regeneration through WNT7B Signaling in Acute Lung Injury

    Scientists found that α7nAChR, α7 nicotinic acetylcholine receptor, coded by Chrna7, was expressed on AT2 cells and was upregulated in response to LPS-induced acute lung injury.
    [JCI Insight]

    AbstractGraphical Abstract

    Extracellular Matrix-Derived Peptide Stimulates the Generation of Endocrine Progenitors and Islet Organoids from iPSCs

    Researchers identified a bioactive peptide domain of type V collagen, WWASKS, through bioinformatic analysis of decellularized pancreatic extracellular matrix-derived collagens.
    [Journal Of Tissue Engineering]

    Full Article

    (Epi)catechin Damage Effects on the Development of Mouse Intestinal Epithelial Structure through the PERK-eIF2α-ATF4-CHOP Pathway

    Intestinal organoids were used as an in vitro model to analyze the effects of four (epi)catechins on the development of the intestinal epithelial structure.
    [Food & Function]

    AbstractGraphical Abstract

    Simultaneous Isolation of Hormone Receptor Positive Breast Cancer Organoids and Fibroblasts Reveals Stroma-Mediated Resistance Mechanisms

    The authors presented an optimized protocol that allows high take-rate, and simultaneous propagation of patient-derived organoids and matching cancer-associated fibroblasts, from primary and metastatic hormone receptor-positive breast cancers.
    [Journal Of Biological Chemistry]

    Full Article

    OrganoidChip Facilitates Hydrogel-Free Immobilization for Fast and Blur-Free Imaging of Organoids

    Researchers presented the OrganoidChip, a microfluidic imaging platform that incorporates a unique design to immobilize organoids for endpoint, fast imaging.
    [Scientific Reports]

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    REVIEWS

    3D Bioprinting for Organ and Organoid Models and Disease Modeling

    The authors focus on how 3D printing technology can enhance the drug discovery process by automating tissue production that enables high-throughput screening of potential drug candidates.
    [Expert Opinion on Drug Discovery]

    Full Article
    INDUSTRY AND POLICY NEWS

    UK ‘Agrees Deal’ to Rejoin EU’s £81Bn Science Program after Being Locked Out for Years

    Britain and the EU have reportedly agreed on a draft deal that would see the UK rejoin the bloc’s Horizon Europe science program – amid warnings that being outside is “damaging” British science.
    [INDEPENDENT]

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    JOB OPPORTUNITIES

    Postdoctoral Fellow – Tumor Microenvironment in Gastrointestinal and Liver Cancer

    Centre for Oncology and Immunology – Hong Kong, Hong Kong

    PhD Scholarship – Organ Bioprinting

    University of Galway – Galway, Ireland

    Postdoctoral Positions – Cancer Drug Persistence & Tumor Microenvironment

    Albert Einstein College of Medicine – New York, New York, United States

    Group Leader – The Molecular Bases of Disease Processes

    Institute of Biology Valrose – Nice, France

    Doctoral Position – Organoid Model for Traumatic Brain Injury

    For­schungs­zentrum Jülich – Jülich, Germany

    > See All Jobs

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