Organoid News Volume 4.28 | Jul 20 2023

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    2023-07-20 | ON 4.28


    Organoid News by STEMCELL Technologies
    Vol. 4.28 – 20 July, 2023
    TOP STORY

    Influenza Vaccine Format Mediates Distinct Cellular and Antibody Responses in Human Immune Organoids

    Using a human tonsil organoid model, scientists tracked the differentiation and kinetics of the adaptive immune response to influenza vaccine and virus modalities.
    [Immunity]

    Full ArticleGraphical Abstract
    Webinar on Modeling arrhythmias using hPSC-derived cardiomyocytes
    PUBLICATIONSRanked by the impact factor of the journal

    Spatially Controlled Construction of Assembloids Using Bioprinting

    Researchers developed a platform, termed Spatially Patterned Organoid Transfer, consisting of an iron-oxide nanoparticle laden hydrogel and magnetized 3D printer to enable the controlled lifting, transport, and deposition of organoids.
    [Nature Communications]

    Full Article

    Lactate-Dependent Transcriptional Regulation Controls Mammalian Eye Morphogenesis

    Utilizing an approach that combined the use of eye organoids and single-cell RNA sequencing, scientists identified specific glucose transporters and glycolytic genes in retinal progenitors.
    [Nature Communications]

    Full ArticlePress Release

    Aerosol Jet-Printed High-Aspect Ratio Micro-Needle Electrode Arrays Applied for Human Cerebral Organoids and 3D Neurospheroid Networks

    The authors presented an aerosol-jet- and inkjet-printing-based method to fabricate microelectrode arrays, equipped with high-aspect ratio μ-needle electrodes that penetrate 3D neural network assemblies.
    [ACS Applied Materials & Interfaces]

    AbstractGraphical Abstract

    Label-Free Imaging of 3D Pluripotent Stem Cell Differentiation Dynamics on Chip

    Investigators developed an approach that enabled dynamic large-scale screening of 3D stem cell cultures based on bright-field imaging.
    [Cell Reports Methods]

    Full ArticleGraphical Abstract

    VGLL4 Promotes Vascular Endothelium Specification via TEAD1 in the Vascular Organoids and Human Pluripotent Stem Cells-Derived Endothelium Model

    Scientists found that vestigial-like family member 4 (VGLL4) was increased during 3D vascular organoids generation and directed differentiation of human embryonic stem cells H1 towards the endothelial lineage.
    [Cellular and Molecular Life Sciences]

    Abstract

    Antitumor Effect of Luteolin Proven by Patient-Derived Organoids of Gastric Cancer

    Researchers elucidated the antitumor activity of luteolin in gastric cancer (GC) patient-derived organoids (PDOs). PDOs were established from GC cancer tissues, and the characterization of tissues and PDOs was performed using whole-exome sequencing.
    [Phytotherapy Research]

    Full Article

    Cisplatin Exhibits Superiority over MMC as a Perfusion Agent in a Peritoneal Mesothelioma Patient Specific Organoid HIPEC Platform

    The authors applied peritoneal mesothelioma patient-derived tumor organoids in elucidating personalized hyperthermic intraperitoneal chemotherapy (HIPEC) responses to bypass rarity of disease in generating preclinical data.
    [Scientific Reports]

    Full Article

    Retinal Organoid Models Show Heterozygous Rhodopsin Mutation Favors Endoplasmic Reticulum Stress-Induced Apoptosis in Rods

    Scientists investigated the impact of rhodopsin mutation on retinal cell differentiation and elucidated the underlying mechanisms of retinitis pigmentosa.
    [Stem Cells and Development]

    Abstract
    Explore virtual support and resources to stay productive and connected with your field.
    REVIEWS

    Advances in Biomimetic Hydrogels for Organoid Culture

    Investigators introduce the challenge of animal-derived decellularised extracellular matrices in organoid culture, and summarize the categories of biomimetic hydrogels currently used for organoid culture.
    [Chemical Communications]

    AbstractGraphical Abstract
    INDUSTRY AND POLICY NEWS

    NIH Grant to Facilitate High-Speed Bioprinting of Bones, Tracheas, Organs

    Developing technology to quickly and efficiently bioprint human tissues at scale is the goal of a new project led by Penn State researchers.
    [The Pennsylvania State University]

    Press Release
    FEATURED EVENT

    Cell Therapy Analytics Symposium

    September 19, 2023
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Tenure-Track Investigator – Alzheimer’s Disease

    National Institutes of Health – Bethesda, Maryland, United States

    Postdoctoral Fellow – Tumor Microenvironment in Gastrointestinal and Liver Cancer

    Centre for Oncology and Immunology – Hong Kong, Hong Kong

    PhD Scholarship – Organ Bioprinting

    University of Galway – Galway, Ireland

    Postdoctoral Positions – Cancer Drug Persistence & Tumor Microenvironment

    Albert Einstein College of Medicine – New York, New York, United States

    Group Leader – The Molecular Bases of Disease Processes

    Institute of Biology Valrose – Nice, France

    > See All Jobs

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