 | | Vol. 4.29 – 27 July, 2023 |
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| Using human embryos and embryo-like assembloids, investigators revealed that WNT, BMP, and Nodal signaling pathways synergistically, but functionally differently, orchestrated human peri-implantation lineage development.
[Cell Research] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors established the colorectal cancer organoid-stroma biobank of matched patient-derived tumor organoids and cancer-associated fibroblasts from 30 patients.
[Cancer Discovery] |
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| Researchers established a patient-derived liver cancer organoid biobank that comprehensively represented the histological and molecular characteristics of various liver cancer types.
[Science Translational Medicine] |
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| Mesenchymal stromal cells and peripheral blood mononuclear cells coculture were used to construct hepatocellular carcinoma (HCC) organoid-on-a-chip mimicking the original tumor microenvironment.
[Advanced Science] |
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| Using kindey organoid models, the authors revealed the regulatory mechanisms of HNF4A and HNF4G during human proximal tubule differentiation.
[Journal of the American Society of Nephrology] |
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| Investigators showed that protocadherin 12 (PCDH12) loss severely impaired cerebral organoid development, with reduced proliferative areas and disrupted laminar organization.
[Cell Reports] |
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| Scientists showed that in human brain slices, rubella virus predominantly infects microglia. By using an organoid-microglia model, they further demonstrated that the infection led to an interferon response in non-microglial cells.
[eLife] |
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| Researchers elaborated on the advantages of the designed controllable perfusion microfluidic chip to promote retinal organoid growth.
[Lab On A Chip] |
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| Scientists developed a monolayer model with an effective barrier function for absorption, distribution, metabolism, and excretion (ADME) assays using rat duodenal organoids as a cell source.
[Scientific Reports] |
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| Researchers showed that human brain organoids provided a detailed and artifact-free window into neuromodulation-evoked electrophysiological effects.
[Heliyon] |
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| The authors summarize the advances and limitations of the state-of-the-art reconstruction platforms for intestinal organoids.
[Cell Death Discovery] |
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| Flinders University researchers were awarded almost $4.5 million in four successful Future Fellowships by the Australian Research Council. This includes Dr. Cedric Bard and their research utilizing human brain organoid models.
[Flinders University] |
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| Researchers from biotechnology startup Axonis are utilizing the International Space Station National Laboratory, to examine how microgravity affects the maturation of human brain cells that form 3D spheroids that mimic certain aspects of the human brain.
[ISS National Laboratory] |
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| October 2 – 4, 2023
Boston, Massachusetts, United States |
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| | Friedrich Miescher Institute for Biomedical Research – Basel, Switzerland |
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| | Harvard Medical School – Boston, Massachusetts, United States |
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| | The University Hospital Essen – Essen, Germany |
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| | National Institutes of Health – Bethesda, Maryland, United States |
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| | Centre for Oncology and Immunology – Hong Kong, Hong Kong |
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