Organoid News Volume 4.33 | Aug 24 2023

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    Noshin Noorjahan
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    2023-08-24 | ON 4.33


    Organoid News by STEMCELL Technologies
    Vol. 4.33 – 24 August, 2023
    TOP STORY

    Organoid Cell Fate Dynamics in Space and Time

    Researchers developed TypeTracker, which identified cell fates by AI-enabled cell tracking and propagating end point fates back along the branched lineage trees.
    [Science Advances]

    Full Article
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    Immune-Infiltrated Kidney Organoid-on-Chip Model for Assessing T Cell Bispecific Antibodies

    Scientists reported an immune-infiltrated, kidney organoid-on-chip model in which peripheral blood mononuclear cells along with nontargeting or targeting T cell bispecific antibody-based tool compounds were circulated under flow.
    [Proceedings Of The National Academy Of Sciences Of The United States Of America]

    Abstract

    Human Placental Mesenchymal Stem Cells Relieve Primary Sclerosing Cholangitis via Upregulation of TGR5 in Mdr2−/− Mice and Human Intrahepatic Cholangiocyte Organoid Models

    Researchers explored the therapeutic potential of human placental MSCs in primary sclerosing cholangitis through the Takeda G protein-coupled receptor 5 (TGR5) receptor pathway.
    [Research]

    Full Article

    APOE Deficiency Impacts Neural Differentiation and Cholesterol Biosynthesis in Human iPSC-Derived Cerebral Organoids

    The authors generated three-dimensional cerebral organoids from human parental iPSC lines and its isogenic apolipoprotein E (APOE)-deficient iPSC line.
    [Stem Cell Research & Therapy]

    Full Article

    Control of Gastruloid Patterning and Morphogenesis by the Erk and Akt Signaling Pathways

    Investigators found that mouse gastruloids contained posterior-to-anterior gradients of Erk and Akt phosphorylation induced by distinct receptor tyrosine kinases.
    [Development]

    Abstract

    Ethanol Causes Cell Death and Neuronal Differentiation Defect during Initial Neurogenesis of the Neural Retina by Disrupting Calcium Signaling in Human Retinal Organoids

    Researchers utilized the hESC derived retinal organoids (hROs) to recapitulate the initial retinal neurogenesis and found that 1% ethanol slowed the growth of hROs by inducing robust cell death and retinal ganglion cell differentiation defect.
    [Stem Cell Reviews and Reports]

    AbstractGraphical Abstract

    Integrative Analysis of Single-Cell RNA-Seq and ATAC-Seq Reveals Heterogeneity of Induced Pluripotent Stem Cell Derived Hepatic Organoids

    To gain deeper insights into transcriptomes and epigenomes of organoids, liver organoids from two states were subjected to single-cell RNA-seq and single-cell ATAC-seq analyses.
    [iScience]

    Full ArticleGraphical Abstract

    Characterization of Neural Mechanotransduction Response in Human Traumatic Brain Injury Organoid Model

    Investigators proposed a novel approach to emulate mild and moderate traumatic brain injury (TBI) using human cerebral organoids that underwent strain rates indicative of TBI.
    [Scientific Reports]

    Full Article

    Deep Learning Model for Predicting Airway Organoid Differentiation

    Scientists identified four biomarkers in RNA extracted from airway organoids. They also predicted biomarker expression by image-based analysis of organoids by convolution neural network, a deep learning method.
    [Tissue Engineering And Regenerative Medicine]

    Abstract

    Study Transportation of Drugs within Newly Established Murine Colon Organoid Systems

    To evaluate the functionality of colonoids, permeability testing was performed with suspensions of 4 and 40 kDa fluorescein isothiocyanate-dextran.
    [Advanced Biology]

    Full Article
    Survey results on the insights and hurdles of CRISPR genome editing.
    REVIEWS

    Bioengineered Skin Organoids: From Development to Applications

    The authors provide an overview of the pivotal work in the progression from 3D layered epidermis to cyst-like skin organoids with appendages.
    [Military Medical Research]

    Full Article

    Organoid: Bridging the Gap between Basic Research and Clinical Practice

    Scientists explore the prominent role of organoid models in basic research and clinical practice from the perspective of tumor biology, tumorigenic microbes-host interaction, clinical decision-making, and regenerative strategy.
    [Cancer Letters]

    Abstract
    INDUSTRY AND POLICY NEWS

    NICO Awards $75,000 Grant for Advanced Organoid Growth in Brain Tumor Research

    Tomas Garzon-Muvdi, MD, MSc, assistant professor of Neurosurgery at Emory University School of Medicine, has been awarded a $75,000 Investigator Initiated Study grant from NICO Corporation.
    [NICO Corporation]

    Press Release
    FEATURED EVENT

    BioCon Asia 2023 – Advanced Cell & Gene Therapy (ACGT) Conference

    October 12 – 13, 2023
    Singapore & Virtual

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    JOB OPPORTUNITIES

    Senior Scientist – Stem Cell Engineering

    Amgen – Burnaby, British Columbia, Canada

    Research Fellow – Mechanobiology Institute

    National University Singapore – Singapore, Singapore

    Research Associate – Recombinant Protein

    Creative Biolabs – New York, New York, United States

    Professorship – Lung Organoids and Tissue Engineering

    University of Giessen – Giessen, Germany

    Professor – Systems Neurobiology

    Goethe University Frankfurt – Frankfurt, Germany

    > See All Jobs

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