Organoid News Volume 4.34 | Aug 31 2023

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    2023-08-31 | ON 4.34


    Organoid News by STEMCELL Technologies
    Vol. 4.34 – 31 August, 2023
    TOP STORY

    Generation of Human Endometrial Assembloids with a Luminal Epithelium Using Air–Liquid Interface Culture Methods

    A novel endometrial assembloid model was developed by combining endometrial epithelial cells and stromal cells, and using an improved matrix and air–liquid interface culture method.
    [Advanced Science]

    Full Article
    Immunofluorescence image of adult stem cell-derived intestinal organoids.
    PUBLICATIONSRanked by the impact factor of the journal

    The Mechano-Chemical Circuit Drives Skin Organoid Self-Organization

    Cell behavior videos showed that the morphological transformation from multiple spheroidal units with morphogenesis competence to planar skin was characterized by two abrupt cell motility–increasing events before calming down.
    [Proceedings Of The National Academy Of Sciences Of The United States Of America]

    Abstract

    A Pillar and Perfusion Plate Platform for Robust Human Organoid Culture and Analysis

    The authors engineered “microarray three-dimensional bioprinting” technology and associated pillar and perfusion plates for human organoid culture and analysis.
    [Advanced Healthcare Materials]

    Abstract

    Druggable Redox Pathways against Mycobacterium abscessus in Cystic Fibrosis Patient-Derived Airway Organoids

    Investigators used human airway organoids microinjected with smooth or rough Mycobacterium abscessus to evaluate bacteria fitness, host responses to infection, and new treatment efficacy.
    [PLOS Pathogens]

    Full Article

    Microfluidic Droplet Encapsulation-Guided Organoid Growth Promotes Parental Tumor Phenotype Recapitulation

    Researchers reported a method of microfluidic droplet encapsulation that provided structural guidance for tumor cell growth and organization, where they developed into tumor organoids with high purity and high rates of modeling success.
    [International Journal of Cancer]

    AbstractGraphical Abstract

    Pancreatic Duct Organoid Swelling Is Chloride-Dependent

    Scientists generated pancreatic duct organoids from cystic fibrosis (CF) and non-CF pigs. Epithelial and ductal origin was confirmed with epithelial markers, ion transporters, and lack of acinar, islet cell markers.
    [Journal of Cystic Fibrosis]

    Abstract

    Development of a Three-Dimensional Organoid Model to Explore Early Retinal Phenotypes Associated with Alzheimer’s Disease

    The authors focused upon the differentiation of hPSCs into retinal organoids for the analysis of early Alzheimer’s disease-associated alterations.
    [Scientific Reports]

    Full Article

    De-Differentiation in Cultures of Organoids from Luminal-Type Breast Cancer Is Restored by Inhibition of NOTCH Signaling

    Investigators prepared organoids from samples obtained from 33 luminal-type breast cancer patients and studied their estrogen receptor expression.
    [Human Cell]

    Abstract

    Transcriptional Signature of Valproic Acid-Induced Neural Tube Defects in Human Spinal Cord Organoids

    Scientists identified and verified the significant changes in cell–cell junctional genes/proteins in valproic acid-treated organoids using transcriptomic and immunostaining analysis.
    [International Journal of Stem Cells]

    Abstract
    A person presenting slides at a scientific conference
    REVIEWS

    Application of Colloidal Photonic Crystals in Study of Organoids

    Investigators review the latest progress in engineering organoids fabricated from colloidal photonic crystals and provide inputs for future research.
    [Advanced Drug Delivery Reviews]

    Full ArticleGraphical Abstract

    Organoids As Complex (Bio)systems

    The author outlines general design principles found in complex systems and demonstrates how these principles manifest within organoids.
    [Frontiers in Cell and Developmental Biology]

    Full Article
    INDUSTRY AND POLICY NEWS

    US Extends Science Pact with China: What It Means for Research

    The US government has extended for six months a key symbolic agreement to cooperate with China in science and technology.
    [Nature]

    Press Release
    FEATURED EVENT

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    JOB OPPORTUNITIES

    Postdoctoral Grant – Retinal Diseases

    Boehringer Ingelheim International – Biberach, Germany

    Assistant Professor – Neural Networks for Biology

    Duke University – Durham, North Carolina, United States

    Senior Scientist – Stem Cell Engineering

    Amgen – Burnaby, British Columbia, Canada

    Research Fellow – Mechanobiology Institute

    National University Singapore – Singapore, Singapore

    Research Associate – Recombinant Protein

    Creative Biolabs – New York, New York, United States

    > See All Jobs

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