Organoid News Volume 4.35 | Sept 07 2023

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    Noshin Noorjahan
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    2023-09-07 | ON 4.35


    Organoid News by STEMCELL Technologies
    Vol. 4.35 – 7 September, 2023
    TOP STORY

    A Patient-Derived Organoid-Based Study Identified an ASO Targeting SNORD14E for Endometrial Cancer through Reducing Aberrant FOXM1 Expression and β-Catenin Nuclear Accumulation

    The Cancer Genome Atlas database was used to determine SNORD14E expression. The effects of SNORD14E were investigated using CCK8, Transwell, wound-healing assays, and a xenograft model experiment; apoptosis was measured by flow cytometry.
    [Journal of Experimental & Clinical Cancer Research]

    Full Article
    A person presenting slides at a scientific conference
    PUBLICATIONSRanked by the impact factor of the journal

    Scalable Production of Tissue-Like Vascularized Liver Organoids from Human PSCs

    Using single-cell RNA sequencing and immunofluorescence, scientists demonstrated a liver-like cellular repertoire, a higher order cellular complexity, presenting with vascular luminal structures, and a population of resident macrophages: Kupffer cells.
    [Experimental & Molecular Medicine]

    Full Article

    Establishment of a Large-Scale Patient-Derived High-Risk Colorectal Adenoma Organoid Biobank for High-Throughput and High-Content Drug Screening

    Investigators established a large-scale patient-derived high-risk colorectal adenoma organoid biobank containing 37 patient-derived organoid lines derived from 33 patients.
    [BMC Medicine]

    Full Article

    Three-Dimensional Molecular Cartography of Human Cerebral Organoids Revealed by Double-Barcoded Spatial Transcriptomics

    The authors developed a cost-effective strategy for manufacturing molecularly double-barcoded DNA arrays that allowed large-scale spatially resolved transcriptomics studies.
    [Cell Reports Methods]

    Full ArticleGraphical Abstract

    Self-Formation of Concentric Zones of Telencephalic and Ocular Tissues and Directional Retinal Ganglion Cell Axons

    Scientists reported self-formation of human telencephalon-eye organoids comprising concentric zones of telencephalic, optic-stalk, optic-disc, and neuroretinal tissues along the center-periphery axis.
    [eLife]

    Full Article

    L1077P CFTR Pathogenic Variant Function Rescue by Elexacaftor–Tezacaftor–Ivacaftor in Cystic Fibrosis Patient-Derived Air–Liquid Interface (ALI) Cultures and Organoids: In Vitro Guided Personalized Therapy of Non-F508del Patients

    Using the innovative approach of using nasal conditionally reprogrammed cell-based models that mimic patient disease in vitro, investigators theratyped orphan cystic fibrosis transmembrane conductance regulator mutation L1077P.
    [Respiratory Research]

    Full Article

    Role of Androgen Signaling in Androgen Receptor-Positive Extramammary Paget’s Disease: Establishment of Organoids and Their Biological Analysis as a Novel Therapeutic Target

    Patient-derived organoids were established and cultured from two androgen receptor-positive Extramammary Paget’s disease patients: one man and one woman.
    [Journal of Dermatological Science]

    Abstract

    Trophoblast Organoids with Physiological Polarity Model Placental Structure and Function

    Researchers developed a method to culture trophoblast organoids under conditions that recapitulated the cellular orientation of chorionic villi in vivo.
    [Journal Of Cell Science]

    Full Article

    Generation of 3D Lung Organoids from Human Induced Pluripotent Stem Cells for Modeling of Lung Development and Viral Infection

    Scientists described a protocol in which hiPSCs underwent stepwise differentiation into definitive endoderm to three-dimensional (3D) lung organoids, which contained both epithelial and mesenchymal cellular architecture and displayed proximal and distal airway patterning.
    [Heliyon]

    Full ArticleGraphical Abstract
    An ISSCR 2022 COREdinates Webinar: Differentiation of High-Quality hPSCs Using STEMdiff ™ and TeSR ™-AOF, presented by Kim Snyder. Click to Watch Now.
    REVIEWS

    Cardiovascular Human Organ-on-a-Chip Platform for Disease Modeling, Drug Development, and Personalized Therapy

    The authors focus on human organ-on-a-chip systems to model cardiovascular diseases, perform drug screening, and advance personalized medicine.
    [Journal of Biomedical Materials Research Part A]

    Abstract
    INDUSTRY AND POLICY NEWS

    UK Finally Rejoins Horizon Europe Research Funding Scheme

    The UK government announced that it will rejoin the European Union’s €95 billion research funding program known as Horizon Europe.
    [ScienceInsider]

    Editorial
    FEATURED EVENT

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    November 11 – 15, 2023
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    JOB OPPORTUNITIES

    Postdoctoral Position – Microbiology

    École Polytechnique Fédérale de Lausanne – Lausanne, Switzerland

    PhD Position – Precision Medicine in Inflammatory Bowel Diseases

    Norwegian University of Science & Technology – Trondheim, Norway

    Laboratory Research Scientist – Human Normal and Leukemic Stem Cells

    Francis Crick Institute – London, England, United Kingdom

    Postdoctoral Grant – Retinal Diseases

    Boehringer Ingelheim International – Biberach, Germany

    Assistant Professor – Neural Networks for Biology

    Duke University – Durham, North Carolina, United States

    > See All Jobs

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