Organoid News Volume 4.36 | Sept 14 2023

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    2023-09-14 | ON 4.36


    Organoid News by STEMCELL Technologies
    Vol. 4.36 – 14 September, 2023
    TOP STORY

    Single-Cell Brain Organoid Screening Identifies Developmental Defects in Autism

    Researchers developed the CRISPR–human organoids–single-cell RNA sequencing system, CHOOSE, which used verified pairs of guide RNAs, inducible CRISPR–Cas9-based genetic disruption, and single-cell transcriptomics for pooled loss-of-function screening in mosaic organoids.
    [Nature]

    Full ArticlePress Release
    An ISSCR 2022 COREdinates Webinar: Differentiation of High-Quality hPSCs Using STEMdiff ™ and TeSR ™-AOF, presented by Kim Snyder. Click to Watch Now.
    PUBLICATIONSRanked by the impact factor of the journal

    3D-Cultured Blastoids Model Human Embryogenesis from Pre-Implantation to Early Gastrulation Stages

    Investigators reported that blastoids cultured on thick three-dimensional extracellular matrices captured hallmarks of early post-implantation development, including epiblast lumenogenesis, rapid expansion and diversification of trophoblast lineages, and robust invasion of extravillous trophoblast cells by day 14.
    [Cell Stem Cell]

    Full ArticleGraphical Abstract

    Human Blood Vessel Organoids Reveal a Critical Role for CTGF in Maintaining Microvascular Integrity

    Scientists used human blood vessel organoids (BVOs) as a model of the microvasculature. BVOs fully recapitulated key features of the human microvasculature, including the reliance of mature endothelial cells on glycolytic metabolism.
    [Nature Communications]

    Full Article

    Zika Virus Targets Human Trophoblast Stem Cells and Prevents Syncytialization in Placental Trophoblast Organoids

    Using human trophoblast stem cells (hTSCs), the authors demonstrated that hTSCs were permissive to Zika virus (ZIKV) infection, and resistance to ZIKV increased with hTSC differentiation.
    [Nature Communications]

    Full Article

    Toxic Effects and Mechanisms of Nanoplastics on Embryonic Brain Development Using Brain Organoids Model

    Investigators focused on the toxic effects of nanoplastics on brain developmental processes by investigating their interactions with brain organoids.
    [Science of The Total Environment]

    AbstractGraphical Abstract

    Polarity Reversal of Canine Intestinal Organoids Reduces Proliferation and Increases Cell Death

    Scientists showed that apical-out organoids had drastically reduced proliferative potential, as evidenced by immunohistochemical staining and the incorporation of the thymidine analog EdU.
    [Cell Proliferation]

    Full Article

    Mimicking Acute Airway Tissue Damage Using Femtosecond Laser Nanosurgery in Airway Organoids

    For characterization of organoids’ response to single or multiple-cell ablation, researchers analyzed overall organoid survival and found that airway organoids were capable of efficiently repairing damage induced by femtosecond laser-based ablation of a single to ten cells within 24 h.
    [Frontiers in Cell and Developmental Biology]

    Full Article

    Grainyhead-Like 2 Is Required for Morphological Integrity of Mouse Embryonic Stem Cells and Orderly Formation of Inner Ear-Like Organoids

    The authors generated different homozygous deletions to knockout grainyhead-like 2 (Grhl2) in mouse embryonic stem cells, including some mimicking naturally occurring truncations in the dimerisation domain related to human deafness autosomal dominant type 28.
    [Frontiers in Cell and Developmental Biology]

    Full Article

    Modeling the Pathology and Treatment of Cardiac Fibrosis in Vascularized Atrial and Ventricular Cardiac Microtissues

    Researchers reported the development of chamber-specific, vascularized hiPSC-derived cardiac microtissues, which allowed for the multi-parametric assessment of cardiac fibrosis.
    [Frontiers in Cardiovascular Medicine]

    Full Article

    Organoids and Metastatic Orthotopic Mouse Model for Mismatch Repair-Deficient Colorectal Cancer

    Scientists generated organoids and an orthotopic mouse model from intestine tumors developed in a Msh2-deficient mouse model, and followed with a detailed characterization.
    [Frontiers in Oncology]

    Full Article

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    REVIEWS

    Bioengineering Approaches for the Pancreatic Tumor Organoids Research and Application

    The authors summarize and analyze the recent developments in engineering pancreatic tumor organoid models.
    [Advanced Healthcare Materials]

    Abstract

    Gastrointestinal Organs and Organoids-on-a-Chip: Advances and Translation Into the Clinics

    Scientists focus on healthy and disease models of: Human Microbiome-on-a-chip and its rising correlation with gastro pathophysiology; Stomach-on-a-chip; Liver-on-a-chip; Pancreas-on-a-chip; Small Intestine, Colon and Colorectal cancer organoids-on-a-chip, and Multi-Organoids-on-a-chip.
    [Biofabrication]

    Abstract
    INDUSTRY AND POLICY NEWS

    Gilbert Family Foundation Contributes Nearly $375 Million in Partnership with Henry Ford Health to Bring Shirley Ryan AbilityLab to Detroit and Create the Nick Gilbert Neurofibromatosis Research Institute

    The Gilbert Family Foundation, Henry Ford Health, and Shirley Ryan Ability Lab announced a historic partnership to bring a 72-bed state-of-the-art physical medicine and rehabilitation facility to Detroit.
    [The State News]

    Press Release
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    JOB OPPORTUNITIES

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    National University of Singapore – Singapore. Singapore

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    Norwegian University of Science & Technology – Trondheim, Norway

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    École polytechnique fédérale de Lausanne – Lausanne, Switzerland

    Postdoctoral Position – Retinal Diseases

    Boehringer Ingelheim International – Biberach, Germany

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