 | | Vol. 4.37 – 21 September, 2023 |
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| Scientists reported the generation of human trunk-like structures that modeled the co-morphogenesis, patterning, and differentiation of the human spine and spinal cord.
[Nature Biotechnology] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| A scalable system was proposed to generate pre-vascularized and functional human beige adipose tissue organoids using the human stromal vascular fraction of white adipose tissue as a source of adipose and endothelial progenitors.
[Advanced Science] |
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| Researchers developed a customized bioreactor that allowed dynamic loading of periodontal ligament-derived fibroblasts. A collagen-based hydrogel mixture was optimized to maintain structural integrity and constant cell growth during stretching.
[Advanced Healthcare Materials] |
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| Investigators developed a microwell-based method that enabled high-throughput quantification of image-based parameters for organoids grown from single cells, which could further be retrieved from their microwells for molecular profiling.
[Cell Systems] |
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| To investigate in vitro neovascularization and various 3D microenvironmental approaches, scientists designed a comprehensive single-cell transcriptomic study.
[Stem Cell Reports] |
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| Researchers explored the efficiency and reliability of a differentiation method, called CYST protocol, that facilitated retina generation by forming neuroepithelial cysts from hiPSC clusters.
[Frontiers in Cellular Neuroscience] |
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| Investigators performed a detailed functional characterization of human intestinal organoid cultures under different conditions with the aim to suggest an optimized ex-vivo model to further analyze inflammation-induced intestinal epithelial barrier dysfunction.
[Frontiers in Cell and Developmental Biology] |
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| The authors assessed the effect of cigarette smoke-exposure and the endoplasmic reticulum stress inducer Thapsigargin on Wnt/β-catenin signaling activation in MRC-5 fibroblasts, and on their ability to support lung epithelial organoid formation.
[Frontiers in Cell and Developmental Biology] |
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| The TRIPLEX study was a single-center observational study conducted to investigate the feasibility of generating patient-derived tumor organoids from triple negative breast cancer and to evaluate their ability to predict clinical response.
[BMC Cancer] |
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| To facilitate in vitro mechanistic studies in pelvic inflammatory disease and subsequent tubal factor infertility, researchers established patient tissue-derived fallopian tube organoids.
[Reproductive Sciences] |
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| Scientists review the available applications of organoids in regenerative medicine and the current challenges concerning this field.
[Stem Cells] |
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| Despite negative feedback from the research community, the US National Institutes of Health (NIH) will move forward with a policy requiring that foreign scientists receiving ‘subawards’ from the agency must share their laboratory notebooks and other raw data with their research partner in the US.
[Nature News] |
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| February 8 – 11, 2024
Cancun, Mexico |
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| | Helmholtz Association of German Research Centres – Berlin, Germany |
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| | KU Leuven – Leuven, Belgium |
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| | Cold Spring Harbor Laboratory – Cold Spring Harbor, New York, United States |
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| | Beth Israel Deaconess Medical Center & Harvard Medical School – Boston, Massachusetts, United States |
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| | ShanghaiTech University – Shanghai, China |
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