 | | Vol. 4.38 – 28 September, 2023 |
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| Researchers integrated assembloids with CRISPR screening to investigate the involvement of 425 neurodevelopmental disorder genes in human interneuron development.
[Nature] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists combined optogenetics and gene perturbation technologies to activate or knock-down RNA of target genes in programmable spatiotemporal patterns.
[Nature Methods] |
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| Investigators developed a microfluidic system which can be used to study heart and kidney interaction in vitro.
[Materials Today Bio] |
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| The authors established a forebrain organoid system and recapitulated early human cortical development spatiotemporally including neuroepithelium induction, apical-basal axis formation, and neural progenitor proliferation and maintenance.
[Environmental Pollution] |
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| Researchers illuminated the bioactivity and mechanisms of sesamol in rheumatoid arthritis (RA) fibroblast-like synoviocytes, and aimed to estimate the potential clinical application value of sesamol in RA treatment.
[Phytomedicine] |
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| Investigators analyzed the response of mouse thyroid organoids to the exposure to a biologically relevant dose range of the phthalates bis(2-ethylhexyl) phthalate, di-iso-decylphthalate, di-iso-nonylphthalate, and di-n-octylphthalate for 24 h.
[Frontiers in Endocrinology] |
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| To investigate whether head and neck cancer organoids could maintain the genetic characteristics of their original tumors and elucidate the clonal evolution process during a long-term passage, researchers performed targeted sequencing, covering 377 cancer-related genes.
[Oral Oncology] |
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| Scientists presented a genetically engineered human cerebral organoid model with a cancer-like phenotype that could provide a basis for glioblastoma-like models.
[Frontiers in Oncology] |
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| Human-derived intestinal organoids were grown from pediatric disorders of gut-brain interaction and non-IBD colon biopsies. Colonoids were treated with 250 nM linaclotide and assayed for cGMP to develop a model of guanylin cyclase C activity.
[Neurogastroenterology And Motility] |
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| The authors present a comprehensive review on the construction methods and potential applications of lung cancer organoids in both preclinical and clinical research.
[Frontiers in Oncology] |
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| There is an urgent need for physiological models to study SARS-CoV-2 infection during the pandemic. Human stem cell-derived organoids can provide insight into understanding the SARS-CoV-2 cell entry molecular mechanism.
[Molecular Biology Reports] |
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| Arc Institute announced the selection of its new fully funded Core Investigator and first Science Fellow, along with its first Innovation Investigators and Ignite Award Recipients.
[Arc Institute] |
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| November 28 – 30, 2023
San Francisco, California, United States |
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| | University of California, San Francisco – San Francisco, California, United States |
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| | Helmholtz Association of German Research Centres – Berlin, Germany |
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| | KU Leuven – Leuven, Belgium |
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| | Cold Spring Harbor Laboratory – Cold Spring Harbor, New York, United States |
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| | Beth Israel Deaconess Medical Center & Harvard Medical School – Boston, Massachusetts, United States |
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