 | | Vol. 4.39 – 5 October, 2023 |
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| The authors described a protocol for improved specification of nephron progenitors from hPSCs that resulted in kidney organoids with elongated proximalized nephrons displaying improved proximal tubule maturity compared with those generated using standard kidney organoid protocols.
[Nature Protocols] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists utilized the hPSC-derived liver organoids to compare the cytotoxicity of pristine polystyrene microplastics and aged polystyrene microplastics ranged from 20 to 200 ng/mL.
[Science of The Total Environment] |
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| Using cerebral organoids (COs) as exemplar, researchers demonstrated the possibility to create bio-instructive hydrogels with tunable stiffness ranging from 0.69 kPa to 2.24 kPa to culture and induce COs growth.
[Acta Biomaterialia] |
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| The authors investigated the anti-colorectal cancer (CRC) effects of fisetin, a natural plant flavonoid. Cytotoxicity was performed in CRC patient-derived organoids.
[Biomedicine & Pharmacotherapy] |
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| Using single-cell RNA sequencing at ten stages during the first 36 days of differentiation, researchers tracked the evolution from pluripotency to various ear cell types after exposure to specific signaling modulators.
[Development] |
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| Scientists established iPSC-derived collagen α5(IV)-expressing kidney organoids and confirmed that kidney organoids from COL4A5 mutation-corrected iPSCs restore collagen α5(IV) protein expression.
[Communications Biology] |
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| Investigators performed a detailed functional characterization of human intestinal organoid cultures under different conditions with the aim to suggest an optimized ex-vivo model to further analyze inflammation-induced intestinal epithelial barrier dysfunction.
[Frontiers in Cell and Developmental Biology] |
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| Researchers investigated the relationship between mitochondrial function and NASH disease by comparing NASH liver organoids and control liver organoids.
[Frontiers in Pharmacology] |
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| Scientists described an efficient method of intestinal organoid editing using a ribonucleoprotein CRISPR-based approach.
[Disease Models & Mechanisms] |
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| Investigators adapted human primary gut organoids grown as monolayers to quantify transcription factor phosphorylation, gene expression, cytokine production, and barrier function.
[Scientific Reports] |
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| The authors discuss how the physical microenvironment modulates critical events during the periods of neurogenesis and neurodevelopment.
[Small] |
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| Scientists review the current state, recent advances, and future challenges in the functional characterization of kidney organoids, strategies to accelerate and enhance kidney organoid functions, and access to PSC resources to advance organoid research.
[American Journal Of Physiology-Renal Physiology] |
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| South Korea’s scientists have been left reeling after the government proposed substantial cuts to the 2024 federal research budget. Government spending on research and development in the country has been among the highest in the world and the announcement has sparked a rare outcry from researchers.
[Nature] |
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| October 23 – 25, 2023
Toronto, Ontario, Canada |
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| | Aspect Biosystems – Vancouver, British Columbia, Canada |
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| | Medical University of South Carolina – Charleston, South Carolina, United States |
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| | University of California, San Francisco – San Francisco, California, United States |
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| | Helmholtz Association of German Research Centres – Berlin, Germany |
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| | KU Leuven – Leuven, Belgium |
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