Organoid News Volume 4.40 | Oct 12 2023

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    Noshin Noorjahan
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    2023-10-12 | ON 4.40


    Organoid News by STEMCELL Technologies
    Vol. 4.40 – 12 October, 2023
    TOP STORY

    Mpox Virus Infection and Drug Treatment Modeled in Human Skin Organoids

    Scientists demonstrated that hiPSC-derived skin organoids were susceptible to Mpox virus infection and support infectious virus production.
    [Nature Microbiology]

    Abstract
    Scientific resources to support your organoids research. Learn More!
    PUBLICATIONSRanked by the impact factor of the journal

    Complement Factor D Targeting Protects Endotheliopathy in Organoid and Monkey Models of COVID-19

    Researchers developed an infection-competent human vascular organoid from PSCs for modeling endotheliopathy. Longitudinal serum proteome analysis identified aberrant complement signature in critically ill patients driven by the amplification cycle regulated by complement factor B and D.
    [Cell Stem Cell]

    Full ArticlePress ReleaseGraphical Abstract

    Regulation of CTCF Loop Formation during Pancreatic Cell Differentiation

    To understand the contribution of CTCF-mediated chromatin organization to cell lineage commitment, investigators analyzed 3D chromatin architecture during the differentiation of human embryonic stem cells into pancreatic islet organoids.
    [Nature Communications]

    Full Article

    Comparative Analysis of Response to Treatments and Molecular Features of Tumor-Derived Organoids versus Cell Lines and PDX Derived from the Same Ovarian Clear Cell Carcinoma

    Scientists established seven models: four cell lines, two patient-derived tumor organoids, and one patient-derived xenograft (PDX), all derived from the same ovarian clear cell carcinoma.
    [Journal of Experimental & Clinical Cancer Research]

    Full Article

    Volumetric Compression by Heterogeneous Scaffold Embedding Promotes Cerebral Organoid Maturation and Does Not Impede Growth

    To accurately replicate the dynamic organoid development observed in nature, investigators presented a method of heterogeneous embedding using an alginate-shell-Matrigel-core system.
    [Cell Systems]

    AbstractGraphical Abstract

    Human Pluripotent Stem Cell-Derived Inner Ear Organoids Recapitulate Otic Development In Vitro

    The authors provided the first direct comparisons of the early human embryonic otocyst and fetal sensory organs with human inner ear organoids.
    [Development]

    Abstract

    Characterization and AAV-Mediated CRB Gene Augmentation in Human Derived CRB1KO and CRB1KOCRB2+/- Retinal Organoids

    CRB1KO and CRB1KOCRB2+/- differentiation day 210 retinal organoids showed a significant decrease in the number of photoreceptor nuclei in a row and a significant increase in the number of photoreceptor cell nuclei above the outer limiting membrane.
    [Molecular Therapy-Methods & Clinical Development]

    AbstractFull ArticleGraphical Abstract

    Quantitative and Qualitative Analysis of Neurotransmitter and Neurosteroid Production in Cerebral Organoids during Differentiation

    Scientists performed quantitative and qualitative assessments of neurotransmitters and neurosteroids over the course of cerebral organoid differentiation.
    [ACS Chemical Neuroscience]

    Full ArticleGraphical Abstract

    TP53-PTEN-NF1 Depletion in Human Brain Organoids Produces a Glioma Phenotype In Vitro

    The authors presented a genetically engineered human cerebral organoid model with a cancer-like phenotype that could provide a basis for glioblastoma-like models.
    [Frontiers in Oncology]

    Full Article

    Establishment of Human Intestinal Organoids Derived from Commercially Available Cryopreserved Intestinal Epithelium and Evaluation for Pharmacokinetic Study

    Investigators established intestinal organoids using commercially available cryopreserved human intestinal epithelial cells and compared their functions with biopsy-derived human intestinal organoids from a pharmacokinetic point of view.
    [Drug Metabolism and Pharmacokinetics]

    Abstract
    Grow Functional Airway Organoids with PneumaCult™
    REVIEWS

    Small Joint Organoids 3D Bioprinting: Construction Strategy and Application

    The authors introduce the biological structure of joint tissues, summarize key procedures in 3D bioprinting for cartilage repair, and propose strategies for constructing joint organoids using 3D bioprinting.
    [Small]

    Abstract

    Vascular Organoids: Unveiling Advantages, Applications, Challenges, and Disease Modeling Strategies

    Scientists present a comprehensive overview of diabetic vasculopathy, demonstrating how the interplay of different vascular cell types is critical for the successful modeling of complex disease processes in vitro.
    [Stem Cell Research & Therapy]

    Full ArticleGraphical Abstract
    INDUSTRY AND POLICY NEWS

    Yale Awarded $4.5M Grant to Investigate Bipolar Disorder

    A group of Yale researchers at the School of Medicine has received a $4.5 million grant to study bipolar disorder.
    [Yale News]

    Press Release

    HHS Releases Notice of Proposed Rulemaking to Update 2005 Public Health Service Policies on Research Misconduct

    The Office of Research Integrity has issued a Notice of Proposed Rulemaking to update the 2005 Public Health Service (PHS) Policies on Research Misconduct. The current regulation establishes the requirements for addressing research misconduct in PHS-funded research.
    [US Department of Health and Human Services]

    Press Release
    FEATURED EVENT

    Generation and Application of Organoid Disease Models

    October 29 – November 3, 2023
    Hinxton, England, United Kingdom

    > See All Events

    JOB OPPORTUNITIES

    Faculty Position – Microfluidics & Biology on Chip

    EPFL – Lausanne, Switzerland

    Faculty Position – Regenerative Medicine and Cell Biology

    Medical University of South Carolina – Charleston, South Carolina, United States

    Assistant Professor – Developmental or Stem Cell Biology

    University of California, San Francisco – San Francisco, California, United States

    Process Development Associate – Bioprinting

    Aspect Biosystems – Vancouver, British Columbia, Canada

    Postdoctoral Position – Next Generation Organoid

    Helmholtz Association of German Research Centres – Berlin, Germany

    > See All Jobs

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