Organoid News Volume 4.41 | Oct 19 2023

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    Noshin Noorjahan
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    2023-10-19 | ON 4.41


    Organoid News by STEMCELL Technologies
    Vol. 4.41 – 19 October, 2023
    TOP STORY

    CD146 Promotes Malignant Progression of Breast Phyllodes Tumor through Suppressing DCBLD2 Degradation and Activating the AKT Pathway

    The efficacy of anti-CD146 monoclonal antibody AA98 against malignant phyllodes tumors (PTs) was corroborated by a malignant PT organoid model and a PT patient-derived xenograft model.
    [Cancer Communications]

    Full Article
    A Labroots 2021 Webinar: iPSCs As Models, Part 2: Modeling the Human Brain with Organoids, presented by Dr. Anjana Nityanandam, Director of the Human Stem Cell Lab core facility at St. Jude Children’s Research Hospital. Click to Watch Now.
    PUBLICATIONSRanked by the impact factor of the journal

    Morphogenesis and Development of Human Telencephalic Organoids in the Absence and Presence of Exogenous Extracellular Matrix

    Scientists showed that exposure to a solubilized basement membrane matrix substrate, Matrigel, at early neuroepithelial stages caused rapid tissue polarization and rearrangement of neuroepithelial architecture.
    [EMBO Journal]

    Full ArticleGraphical Abstract

    Deciphering Neuronal Deficit and Protein Profile Changes in Human Brain Organoids from Patients with Creatine Transporter Deficiency

    Investigators generated human brain organoids from induced pluripotent stem cells of healthy subjects and creatine transporter deficiency (CTD) patients. Brain organoids from CTD donors had reduced creatine uptake compared with those from healthy donors.
    [eLife]

    Full Article

    Transcriptomic and Morphological Maturation of Human Astrocytes in Cerebral Organoids

    Researchers generated cerebral organoids from three healthy individuals and assessed astrocyte maturation after 5, 11, 19, and 37 weeks in culture.
    [Glia]

    Full Article

    Silicate Microfiber Scaffolds Support the Formation and Expansion of the Cortical Neuronal Layer of Cerebral Organoids with a Sheet-Like Configuration

    The authors discovered that silicate microfiber scaffolds could support the formation of cortical neuronal layers and successfully generated cortical neuronal layers, which were nine times thicker than conventional cerebral organoids, in 70 days.
    [Stem Cells Translational Medicine]

    AbstractGraphical Abstract

    T Cell Mediated Immune Rejection of Beta-2-Microglobulin Knockout Induced Pluripotent Stem Cell-Derived Kidney Organoids

    To address immune rejection, scientists investigated the impact of genetically modifying human leukocyte antigen class I in kidney organoids prior to transplantation.
    [Stem Cells Translational Medicine]

    Full ArticleGraphical Abstract

    Synthetic Augmentation of Bilirubin Metabolism in Human Pluripotent Stem Cell-Derived Liver Organoids

    Researchers used iPSCs to develop human liver organoids that can emulate conjugation failure phenotype. Bilirubin conjugation assays, chromatin immunoprecipitation, and transcriptome analysis elucidated the role of glucocorticoid antagonism in UDP glucuronosyltransferase family 1 member A1 activation.
    [Stem Cell Reports]

    Full ArticleGraphical Abstract

    Patient-Derived Organoids as Personalized Avatars and a Potential Immunotherapy Model in Cervical Cancer

    To model individual responses to adoptive T cell therapy, scientists expanded tumor-infiltrating lymphocytes ex vivo and co-cultured them with paired organoids.
    [iScience]

    AbstractFull ArticleGraphical Abstract

    Single-Cell Characterization of Self-Renewing Primary Trophoblast Organoids as Modeling of EVT Differentiation and Interactions with Decidual Natural Killer Cells

    Researchers generated the self-renewing trophoblast organoid from human placental villous and differentiated it into extravillous trophoblast cells (EVTs) for investigating the differentiation events.
    [BMC Genomics]

    Full Article
    Survey results on the needs and challenges in the human pluripotent stem cell field
    REVIEWS

    Advances in Organoid Technology for Veterinary Disease Modeling

    The authors discuss several definitions used in organoid research and highlight the currently known achievements in modeling veterinary diseases, including infectious and inflammatory diseases, cancers, and metabolic diseases.
    [Frontiers In Veterinary Science]

    Full Article
    INDUSTRY AND POLICY NEWS

    Argentina Election: Front Runner Vows to Slash Science Funding

    Scientists in Argentina are on edge as the country’s presidential election approaches. If elected, Javier Milei has pledged to eliminate government spending on research and shut down the environment and health ministries.
    [Nature]

    Press Release
    FEATURED EVENT

    CRISPR Virtual Event Series 2023

    November 11, 2023
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    JOB OPPORTUNITIES

    Postdoctoral Research Associate – Mechanical Vulnerabilities in Cells

    University of Liverpool – Liverpool, England, United Kingdom

    Postdoctoral Fellow – Intestinal Stem Cell and Cancer

    Francis Crick Institute – London, England, United Kingdom

    Doctoral Positions – Biomedical Research

    Berlin Institute of Health at Charit̩ РBerlin, Germany

    Faculty Position – Microfluidics & Biology on Chip

    EPFL – Lausanne, Switzerland

    Process Development Associate – Bioprinting

    Aspect Biosystems – Vancouver, British Columbia, Canada

    > See All Jobs

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