 | | Vol. 4.42 – 26 October, 2023 |
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| Researchers established a method for transplanting intestinal organoids into intestinal ischemia-reperfusion mice.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists identified a gut-lung axis driven by intestinal antimicrobial peptide (AMP) expression and mediated by the intestinal microbiota that is linked to lung injury in newborns.
[Microbiome] |
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| Investigators studied human iPSC-derived hepatic organoids and identified a robust induction in DIO2 expression that occurred in hepatoblasts.
[JCI Insight] |
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| In a 3D organoid model, injured PDGFRα+ fibroblast-supported organoids were morphologically distinct from those cultured with normal fibroblasts, and scRNA-Seq analysis suggested distinct transcriptomic changes in alveolar epithelia supported by injured PDGFRα+ fibroblasts.
[JCI Insight] |
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| An organoid culture model was developed to regenerate articular cartilage by sequential treatment with BMP2 and BMP9 that parallels induced joint regeneration at digit amputation wounds in vivo.
[Development] |
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| Scientists reported the next generation and selection of a potent MAPK13-14 inhibitor that more effectively down-regulated type-2 cytokine-stimulated mucus production in air-liquid interface and organoid cultures of human airway epithelial cells.
[American Journal Of Physiology-Lung Cellular And Molecular Physiology] |
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| TMEM107 deficiency in retinal organoids resulted in the loss of primary cilia, down-regulation of retina-specific genes, and cyst formation.
[Life Science Alliance] |
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| Researchers showed that the level of Scribble is decreased in inflammatory bowel disease patients and mice with DSS-induced colitis.
[Scientific Reports] |
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| Investigators explored the technology of tumor organoids and discuss the fundamental application of cytology as a simple and cost-effective approach toward organoid development.
[Cancer Cytopathology] |
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| The authors provide an overview of emerging kidney organoid and tubuloid models and focus on the most recent developments that utilize their functional capabilities.
[Trends In Cell Biology] |
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| “Our goal of delivering human data faster to transform neurological R&D takes a major step forward with the addition of the microBrain platform, team and facilities,” AxoSim CEO and co-founder Lowry Curley, Ph D.
[Fierce Biotech] |
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| December 1 – 3, 2023
Chicago, Illinois, United States |
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| | Utrecht University – Utrecht, Netherlands |
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| | University of Notre Dame – Notre Dame, Indiana, United States |
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| | University of Liverpool – Liverpool, England, United Kingdom |
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| | Francis Crick Institute – London, England, United Kingdom |
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| | Berlin Institute of Health at Charité – Berlin, Germany |
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