 | | Vol. 4.43 – 2 November, 2023 |
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| Investigators generated microglia-sufficient brain organoids by coculturing brain organoids with primitive-like macrophages generated from the same hiPSC.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Mechanistically, mutant p53, unlike the wild-type counterpart, induced the expression of serine-synthesis-pathway enzymes and L-type amino acid transporter 1/CD98 heavy chain heterodimer.
[Nature Communications] |
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| Investigators established a Jamaican fruit bat intestinal organoid model of SARS-CoV-2 infection.
[Nature Communications] |
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| Researchers presented a scalable functional precision medicine platform called Drug Efficacy Testing in 3D Cultures, where the response of patient cells to drugs and drug combinations was quantified with live-cell imaging.
[NPJ Precision Oncology] |
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| Scientists demonstrated that cerebral organoids derived from three Alzheimer’s disease (AD)-iPSC lines with PSEN1(A246E) or PSEN2(N141I) mutations developed the AD-specific markers in vitro, yet they also uncovered tissue patterning defects and altered development.
[Cell Reports] |
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| Researchers summarize different types of anti-cancer drug-induced cardiotoxicities and present an extensive overview of the applications of hiPSC-derived cardiac microtissues, cardiac organoids, and heart-on-chips in cardiotoxicity.
[Cell Biology And Toxicology] |
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| Investigators demonstrated a novel experimental approach, based on multi-color, fluorescent tagging of cell nuclei, in combination with picoliter droplet deposition, to study the clonal dynamics in two- and three-dimensional cell cultures.
[Scientific Reports] |
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| Researchers differentiated midbrain-specific brain organoids from iPSC-lines derived from three apparently healthy individuals using a matrix-free, bioreactor method.
[PLOS One] |
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| Scientists used an organoid system to investigate the roles of these fibroblast growth factors in regulating bladder urothelium differentiation and identified their distribution patterns in the mouse bladder.
[BMC Urology] |
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| The authors present a systematic review of studies that have tested the performance of patient-derived organoids to predict the effect of anti-cancer therapies in colorectal cancer, for chemotherapies, targeted drugs, and radiation therapy.
[Scientific Reports] |
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| From research on microbes to studies on brain organoids, a new pharmaceutical lab, and the role of mucus in medication delivery, several payloads launching on SpaceX’s 29th Commercial Resupply Services mission to the International Space Station aim to prevent or treat disease.
[ISS National Laboratory] |
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| November 28 – 30, 2023
Philadelphia, Pennsylvania, United States |
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| | Utrecht University – Utrecht, Netherlands |
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| | University of Notre Dame – Notre Dame, Indiana, United States |
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| | Berlin Institute of Health at Charit̩ РBerlin, Germany |
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| | EPFL – Lausanne, Switzerland |
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| | Medical University of South Carolina – Charleston, South Carolina, United States |
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