 | | Vol. 4.44 – 9 November, 2023 |
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| Researchers described the development of a long-term adult stem cell-derived mammary mini gland culture system that supported robust three-dimensional outgrowths.
[Nature Methods] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| To better understand the etiology of Cronkhite-Canada Syndrome, investigators generated human intestinal organoids from intestinal stem cells isolated from two patients.
[Journal Of Clinical Investigation] |
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| Scientists developed organoid-based single-cell CRISPR screening analyzed with regulons, a framework using regulon activities as readouts to dissect gene knockout effects in organoids.
[Genome Biology] |
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| Researchers described a human cerebral organoid model of bipolar disorder that exhibited altered neural development, elevated neural network activity, and a major shift in the transcriptome.
[Molecular Psychiatry] |
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| Cultures of intestinal organoids revealed that IL-38 functioned as a growth factor by increasing organoid size via inducing WNT3a. In contrast, organoids from IL-38-deficient mice developed more slowly.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| The authors reported the establishment of a long-term 3D organoid-like model derived from a Sarcomatoid Urothelial Bladder Cancer (SARC) patient, SarBC-01.
[npj Precision Oncology] |
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| Scientist employed organoid modeling to evaluate candidate oncogenic loci identified via integrative computational analysis of extreme copy gains overlapping with extreme expression dysregulation in The Cancer Genome Atlas.
[Cell Reports] |
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| Investigators showed 3D organoids generated from liver stem cells from actively Hepatitis C virus-infected individuals carried replicating virus and maintained low-grade infection over months.
[mBio] |
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| Researchers cultured human kidney organoids derived from iPSCs expand and treated human kidney organoids grown by both three-dimensional and transwell protocols with cell-free hemoglobin for 48 hours.
[Disease Models & Mechanisms] |
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| The authors review recent developments in cancer-on-chip models, focusing on three main tumor microenvironment components: the anisotropic extracellular matrix architectures, the vasculature, and the immune system.
[Trends in Biotechnology] |
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| Scientists discuss the culture techniques of intestinal organoids and describe the use of intestinal organoids as research tools for intestinal diseases.
[Stem Cell Reviews and Reports] |
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| The International Society for Stem Cell Research (ISSCR) and publisher Cell Press announced the extension of their partnership to publish the ISSCR’s open-access, peer-reviewed journal, Stem Cell Reports.
[The International Society for Stem Cell Research] |
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| December 2 – 6, 2023
Boston, Massachusetts, United States |
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| | China Pharmaceutical University – Nanjing, Jiangsu, China |
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| | University of Galway – Galway, Ireland |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | University of Notre Dame – Notre Dame, Indiana, United States |
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