 | | Vol. 4.45 – 16 November, 2023 |
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| The authors showed that senescent cells accumulated in aged human brain organoids and that senolytics reduced age-related inflammation and rejuvenated transcriptomic aging clocks.
[Nature Aging] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers evaluated human liver organoid models of metabolic dysfunction-associated steatotic liver disease, comparatively testing disease induction in three conditions: oleic acid, palmitic acid, and TGF-β1.
[EMBO Journal] |
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| Investigators reported that the expression profile of antimicrobials produced by Paneth cells was dramatically askew in human small intestinal organoids as compared to that in paired tissue from which they were derived, with a reduction of α-defensins to nearly undetectable levels.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| Th authors combined impedance biosensors and live imaging for real-time spatiotemporal analysis of olfactory epithelium organoids morphological and physiological features during Alzheimer’s disease progression.
[Biosensors and Bioelectronics] |
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| Scientists developed a 3D printing pipeline for the fabrication of tailor-made culturing platforms for fluidically connected but spatially separated brain organoid array culture.
[Biofabrication] |
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| Researchers explored the changes in chromatin accessibility and transcriptional programs for cochlear hair cell differentiation from postmitotic supporting cells using organoids from postnatal cochlea.
[Cell Reports] |
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| To recapitulate the pancreatic ductal adenocarcinoma (PDAC) tumor microenvironment ex vivo, investigators cocultured patient-derived PDAC cells with mesenchymal and vascular endothelial cells derived from hiPSCs to create a fused pancreatic cancer organoid in an air-liquid interface.
[Cell Reports] |
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| Scientists reported that human skeletal muscle organoids could be differentiated from iPSC lines to contain paraxial mesoderm and neuromesodermal progenitors and develop into organized structures reassembling neural plate border and dermomyotome.
[eLife] |
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| By performing beat rate measurement, histological analysis, contractility analysis, and multi-electrode array, it was verified that the developed method could significantly improve functional recovery and survival of heart organoids after freezing and thawing.
[Biotechnology Journal] |
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| The authors summarize the latest developments in lung organoid technology and their applicability for disease modeling and outline their strengths, drawbacks, and potential avenues for future development.
[Journal Of Clinical Investigation] |
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| Article-processing charges (APC) levied by publishers on authors have become an integral — and sometimes unpopular — part of the open-access revolution. Other options are being explored.
[Nature] |
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| December 4 – 6, 2023
Vienna, Austria |
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| | Applied Stem Cell – Milpitas, California, United States |
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| | China Pharmaceutical University – Nanjing, Jiangsu, China |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | University of Galway – Galway, Ireland |
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| | Baylor College of Medicine – Houston, Texas, United States |
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