 | | Vol. 4.47 – 30 November, 2023 |
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| The authors established a human cardioid platform that recapitulated the development of all major embryonic heart compartments, including right and left ventricles, atria, outflow tract, and atrioventricular canal.
[Cell] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers combined a 3D genome, RNA, accessibility and methylation sequencing method with immunoFACS and RNA sequencing in cortical organoids to map the cell-type-specific regulatory landscape of human neural development across multiple epigenetic layers.
[Nature Cell Biology] |
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| Scientists showed that initiating neural induction in a temporal stepwise gradient guided the generation of brain organoids composed of a single, self-organized apical-out neuroepithelium.
[Nature Communications] |
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| The suitability of the microfluidic device for dynamic 3D cell culture was tested by growing human hepatocytes in the device under controlled fluid flow for a 14-day period.
[Advanced Science] |
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| Researchers demonstrated that microfluidic patient-derived cancer organoids were phenotypically and genotypically similar to the gold-standard Matrigel organoids with the advantages of 1) spheroid uniformity, 2) minimal cell number requirement, and 3) not relying on Matrigel.
[Advanced Science] |
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| Investigators found that N-acetylneuraminic acid synthase mutation resulted in the absence of both sialic acid and protein polysialylation in the cortical organoids and notably reduced the proliferation and expansion of neural progenitors.
[Science Advances] |
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| Scientists showed that the PTENG132D allele disrupted early neuroectoderm formation during the first several days of organoid generation, and results in deficient electrophysiology.
[Molecular Psychiatry] |
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| Researchers derived organoids from the small intestine from a cohort of healthy individuals. Culturing intestinal epithelium on a flat laminin matrix induced their differentiation, facilitating analysis of microbial responses via the apical membrane normally exposed to the luminal content.
[Gut Microbes] |
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| A porous gold membrane electrode was placed directly beneath the cells for in situ and real-time measurements of nitrous oxide.
[Analytical Chemistry] |
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| The authors describe the significance of patient-derived microphysiological systems in precision medicine as well as their unique capacity to offer valuable insights into individual patient characteristics.
[Advanced Healthcare Materials] |
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| The whole genomes of 500,000 people in the UK Biobank will help researchers to probe our genetic code for links to disease.
[Nature News] |
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| January 10 – 13, 2024
Radstadt, Austria |
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| | Ottawa Hospital Research Institute – Ottawa, Ontario, Canada |
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| | University of Exeter – Exeter, England, United Kingdom |
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| | Swammerdam Institute for Life Sciences – Amsterdam, Netherlands |
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| | Royal College of Surgeons in Ireland – Dulin, Ireland |
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| | Applied Stem Cell – Milpitas, California, United States |
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