Organoid News Volume 4.48 | Dec 7 2023

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    2023-12-07 | ON 4.48


    Organoid News by STEMCELL Technologies
    Vol. 4.48 – 7 December, 2023
    TOP STORY

    In Vitro Modeling of the Human Dopaminergic System Using Spatially Arranged Ventral Midbrain–Striatum–Cortex Assembloids

    Scientists developed a human in vitro model that recapitulated key aspects of dopaminergic innervation of the striatum and cortex.
    [Nature Methods]

    Full ArticleGraphical Abstract
    Grow Functional Airway Organoids with PneumaCult™
    PUBLICATIONSRanked by the impact factor of the journal

    Development of Physiologically Relevant Skin Organoids from Human Induced Pluripotent Stem Cells

    The authors used three human induced pluripotent stem cells lines to generate complex skin organoids with stratified skin layers and pigmented hair follicles, with different efficacies.
    [Small]

    Full Article

    Patient- and Xenograft-Derived Organoids Recapitulate Pediatric Brain Tumor Features and Patient Treatments

    Researchers presented a protocol that enabled efficient generation, expansion, and biobanking of pediatric brain cancer organoids.
    [EMBO Molecular Medicine]

    Full ArticleGraphical Abstract

    Murine Trophoblast Organoids as a Model for Trophoblast Development and CRISPR-Cas9 Screening

    The authors established culture conditions for the establishment, maintenance, and differentiation of murine trophoblast organoids.
    [Developmental Cell]

    AbstractGraphical Abstract

    The Impact of Extracellular Matrix on the Precision Medicine Utility of Pancreatic Cancer Patient-Derived Organoids

    Scientists tested the impact of basement membrane extract source on proliferation, drug response, and gene expression in mouse and human pancreatic ductal adenocarcinoma organoids.
    [JCI Insight]

    Abstract

    Potent and Selective Binders of the E3 Ubiquitin Ligase ZNRF3 Stimulate Wnt Signaling and Intestinal Organoid Growth

    Researchers highlighted a strategy for the development of potent, biologically active Wnt signaling pathway agonists via targeting of ZNRF3.
    [Cell Chemical Biology]

    Abstract

    Spatially Segregated Defects and IGF1-Responsiveness of Hilar and Peripheral Biliary Organoids from a Model of Alagille Syndrome

    Hilar and peripheral Jag1Ndr/Ndr intrahepatic cholangiocyte organoids exhibited differences in Notch signaling status, proliferation, and cholangiocyte commitment which may result in cholangiocyte-to-hepatocyte transdifferentiation.
    [Liver International]

    Full Article

    CRX Haploinsufficiency Compromises Photoreceptor Precursor Translocation and Differentiation in Human Retinal Organoids

    Scientists created monoallelic CRX by replacing one allele with tdTomato in hESCs and subsequently dissect pathogenesis in hESCs-derived retinal organoids.
    [Stem Cell Research & Therapy]

    Full Article

    Efficient Generation of Brain Organoids Using Magnetized Gold Nanoparticles

    Investigators presented a method for effectively generating cerebral organoids by using electromagnetic gold nanoparticles (AuNPs). By exposing mature cerebral organoids to magnetized AuNPs, they were able to cultivate them in less than three weeks.
    [Scientific Reports]

    Full Article
    Request a free copy of this wallchart for an overview of the different types of pluripotent cells
    REVIEWS

    Applications of Lung Cancer Organoids in Precision Medicine: from Bench to Bedside

    The authors examine the current state-of-the-art technologies and applications relevant to the formation of lung cancer organoids, as well as the potential of organoids in precision medicine and drug testing.
    [Cell Communication and Signaling]

    Full Article
    INDUSTRY AND POLICY NEWS

    Inventia Life Science Announces Third Dimension Grant for 3D Cell Culture Research

    Inventia Life Science launched the Inventia Third Dimension Grant. This grant will allow researchers studying fundamental biology or drug development to model and test hypotheses using 3D cell cultures.
    [Inventia Life Science (Business Wire)]

    Press Release
    FEATURED EVENT

    Tandem Meetings Transplantation & Cellular Therapy Meetings of ASTCT® and CIBMTR®

    February 21 – 24, 2024
    San Antonio, Texas, United States

    > See All Events

    JOB OPPORTUNITIES

    Research Associate – Lung Fibrosis

    Cedars-Sinai – Los Angeles, California, United States

    Research Associate – PSCs and ESCs

    UCLA Blood Stem Cell Research Center – Los Angeles, California, United States

    Assistant Professor – Stem Cells and Regenerative Medicine

    Ottawa Hospital Research Institute – Ottawa, Ontario, Canada

    Assistant Professor Position – 3D Tissue Organoids

    Swammerdam Institute for Life Sciences – Amsterdam, Netherlands

    Postdoctoral Research Associate – Stem Cell Biology

    University of Sydney – Camperdown, Australia

    > See All Jobs

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