 | | Vol. 5.00 – 4 January, 2024 |
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| Inhibition of an epidermal growth factor receptor/Erb-B2 receptor (EGFR/ERBB2)-signaling network in pancreatic ductal adenocarcinoma organoid-derived cultures and mouse models differentially impacted distinct cancer-associated fibroblasts subtypes.
[Cancer Cell] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators showed that patient-derived intestinal organoids and tumouroids supplemented with immune cells could be used to study the on-target off-tumour toxicities of T cell-engaging bispecific antibodies (TCBs).
[Nature Biomedical Engineering] |
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| Single-cell analysis revealed that a myriad of metabolic changes occurred during cystogenesis, including defective autophagy. Experimental activation of autophagy via ATG5 overexpression or primary cilia ablation significantly inhibited cystogenesis in olycystic kidney disease kidney organoids.
[Cell Stem Cell] |
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| Scientists reported a human organoid model capable of developing the complex cellular diversity of the fetal cerebellum, including a human-specific rhombic lip progenitor population that have never been generated in vitro prior to this study.
[Cell Stem Cell] |
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| Researchers presented a human apical-out airway organoid using a biochemically defined hybrid hydrogel system. During human nasal epithelial progenitor cell differentiation, the gel gradually degraded, leading to the organoid apical surfaces facing outward.
[Nature Communications] |
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| The authors reported Cellos, an accurate, high-throughput pipeline for 3D organoid segmentation using classical algorithms and nuclear segmentation using a trained Stardist-3D convolutional neural network.
[Nature Communications] |
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| Researchers adapted the skin organoid model, inducing the dermal mesenchyme to transform into mammary-specific mesenchyme via the sequential activation of Bone Morphogenetic Protein 4 and Parathyroid Hormone-related Protein and inhibition of hedgehog signaling.
[Developmental Cell] |
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| Investigators describe a large-scale method for producing homogeneous hiPSC-derived cardiac spheroids and cardiac organoids without scaffolds using a porous 3D microwell substratum with a suction system.
[Cell Reports Methods] |
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| The authors generated isogenic iPSCs carrying the hotspot OPA1 c.2708_2711delTTAG mutation and found that the mutant variant caused defective initial and terminal differentiation and abnormal electrophysiological properties of organoid-derived retinal ganglion cells.
[Stem Cell Reports] |
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| Scientists discuss a set of six complementary hallmarks in the context of some of the best-understood adult stem cell niches.
[Cell Stem Cell] |
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| Dozens of science and technology development payloads returned to Earth from the ISS as SpaceX’s 29th Commercial Resupply Services mission, contracted by NASA, successfully concluded.
[ISS National Lab] |
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| February 24 – 25, 2024
Galveston, Texas, United States |
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| | Human Technopole – Location |
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| | Human Technopole – Milan, Italy |
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| | Guangzhou Institutes of Biomedicine and Health – Guangzhou, China |
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| | H. Lee Moffitt Cancer Center & Research Institute – Tampa, Florida, United States |
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| | Ottawa Hospital Research Institute – Ottawa, Ontario, Canada |
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Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
