 | | Vol. 5.02 – 18 January, 2024 |
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| Scientists overlapped differentially expressed genes with publicly available microarray datasets and performed functional in vitro studies to model gene expression changes observed in Crohn’s disease Tregs and to test predicted therapeutics.
[Gastroenterology] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Natural killer cell activation on NKp44/HLA-DP interactions was assessed in vitro using plate-bound HLA-DP molecules and HLA-DPB wildtype versus knock-out human cholangiocyte organoids.
[Gut] |
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| Semaglutide was incorporated into poly(lactic-co-glycolic acid)-poly(ethylene glycol) nanoparticles to improve its delivery across the intestinal barrier.
[Journal Of Controlled Release] |
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| A dual pump-less recirculating Organ-on-Chip platform that combined human pluripotent stem cell-derived liver and stem cell derived-islet organoids was presented.
[Advanced Healthcare Materials] |
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| The authors generated magnetized nanofibers by electrospinning magnetic nanoparticles dispersed in poly-L-lactic acid solution, which were then coated with polydopamine (PD). These PD-coated magnetic fibers had magnetic-responsive properties when incorporated into human dermal fibroblast spheroids.
[Biofabrication] |
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| Scientists introduced a bioelectronic approach to control cortical organoid activity with the selective delivery of ions and neurotransmitters.
[Cell Reports Methods] |
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| Investigators employed fibroblast-organoid or fibroblast-spheroid co-culture systems and time-lapse imaging to reveal that physical contact between fibroblasts and epithelial cells and fibroblast contractility are required to induce mammary epithelial branching.
[PLOS Biology] |
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| Scientists exploited the use of newly developed highly defined hydrogels as potential matrices for the culture of liver organoids and compared them to Matrigel and two hydrogels that were already researched in the field of organoid research.
[Biomacromolecules] |
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| By transplanting midbrain organoid cells into the striatum region of a 6-OHDA-lesioned Parkinson’s disease mouse model, researchers found that the transplanted cells survived and highly efficiently differentiated into dopaminergic neurons.
[Heliyon] |
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| The authors summarize the latest developments in bioengineering functional islet organoids in vitro and promoting vascularization of organoid grafts before and after transplantation.
[Metabolism Clinical And Experimental] |
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| The authors discuss conventional planar approaches and emerging 3D microinstrumentation necessary for advanced organoid-machine interfaces.
[Advanced Healthcare Materials] |
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| The Louisville-based National Stem Cell Foundation (NSCF) is delighted to be part of the third Axiom Space commercial astronaut mission to the International Space Station, scheduled to launch January 18 from the Kennedy Space Center at Cape Canaveral, Florida.
[National Stem Cell Foundation] |
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| March 18 – 19, 2024
London, England, United Kingdom |
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| | University of Alberta – Edmonton, Alberta, Canada |
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| | Karolinska Institutet – Solna, Sweden |
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| | Karolinska Institutet – Solna, Sweden |
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| | The Francis Crick Institute – London, England, United Kingdom |
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| | Human Technopole – Milan, Italy |
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