Organoid News Volume 5.03 | Jan 25 2024

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    Noshin Noorjahan
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    2024-01-25 | ON 5.03


    Organoid News by STEMCELL Technologies
    Vol. 5.03 – 25 January, 2024
    TOP STORY

    Kirigami Electronics for Long-Term Electrophysiological Recording of Human Neural Organoids and Assembloids

    The authors developed flexible electronics that transition from a two-dimensional to a three-dimensional basket-like configuration with either spiral or honeycomb patterns to accommodate the long-term culture of organoids in suspension.
    [Nature Biotechnology]

    AbstractPress Release
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    IL32 Downregulation Lowers Triglycerides and Type I Collagen in Di-Lineage Human Primary Liver Organoids

    Researchers demonstrated in vitro that incubation with IL-32β protein led to an increase in intracellular triglyceride synthesis, while downregulation of IL32 by small interfering RNA leads to lower triglyceride synthesis and secretion in organoids from human primary hepatocytes.
    [Cell Reports Medicine]

    Full ArticleGraphical Abstract

    Towards Label-Free Standardization in 3D Cell Culture: Automated, Selective and Gentle High-Throughput Handling of Spheroids and Organoids via Novel Pick-Flow-Drop Principle

    Using microfluidic flow generated by a piezoelectric droplet generator, aggregates were aspirated from a reservoir on one side of a thin capillary and deposited on the other side, encapsulated in free-flying nanoliter droplets to a target.
    [Advanced Healthcare Materials]

    Abstract

    A Modular Microfluidic Organoid Platform Using LEGO®-like Bricks

    Scientists developed a modular, tubeless fluidic circuit board coupled with reversibly sealed cell culture bricks for dynamic culture of ESC-derived thyroid follicles.
    [Advanced Healthcare Materials]

    Abstract

    Ex Vivo Modeling of Acquired Drug Resistance in BRAF – Mutated Pancreatic Cancer Organoids Uncovers Individual Therapeutic Vulnerabilities

    Investigators reported the ex vivo modeling of acquired drug resistance by creating a pancreatic ductal adenocarcinoma patient-derived tumor organoid model harboring a rare BRAF R506_K507ins VLR mutation resulting in a resistance to trametinib, a MEK inhibitor.
    [Cancer Letters]

    Full Article

    LUBAC-Mediated M1 Ub Regulates Necroptosis by Segregating the Cellular Distribution of Active MLKL

    Researchers identified linear ubiquitin chain assembly complex (LUBAC)-mediated M1 poly-ubiquitination as novel checkpoint for necroptosis regulation downstream of activated mixed lineage kinase domain-like (MLKL) in cells of human origin.
    [Cell Death & Disease]

    Full Article

    Schizophrenia Endothelial Cells Exhibit Higher Permeability and Altered Angiogenesis Patterns in Patient-Derived Organoids

    To model the neuropathology of schizophrenia during early critical periods of brain development, the authors utilized patient-derived iPSCs to generate 3D cerebral organoids and define cell-specific signatures of disease.
    [Translational Psychiatry]

    Full Article

    Establishment of Tumor Microenvironment-Preserving Organoid Model from Patients with Intracranial Meningioma

    The biological features of meningioma organoids (MNOs) were evaluated using WST, LDH, and collagen-based 3D invasion assays.Cellular identities in MNOs were confirmed by immunohistochemistry.
    [Cancer Cell International]

    Full Article

    Gastric Cancer Patient-Derived Organoids Model for the Therapeutic Drug Screening

    Patient-derived organoids (PDOs) were established from surgically resected gastric cancer tumor tissues. Histological and molecular characterization of PDOs and primary tissues were performed via IHC and sequencing analysis.
    [Biochimica Et Biophysica Acta-General Subjects]

    Abstract
    A person presenting slides at a scientific conference
    REVIEWS

    The Promise and Potential of Brain Organoids

    The authors examine the techniques behind organoid generation, their current and potential applications, and future directions for the field. Brain organoids possess complex architecture containing various neural cell types, synapses, and myelination.
    [Advanced Healthcare Materials]

    Abstract

    Organoids as a Tool to Study the Impact of Heterogeneity in Gastrointestinal Epithelium on Host-Pathogen Interactions

    Focusing on the gastrointestinal tract, investigators provide an overview of cellular differentiation in vivo and in organoids and how differentiation in organoids and their derived models are used to advance our understanding of viral, bacterial, and parasitic infection.
    [Clinical and Experimental Immunology]

    Abstract
    Graphical Abstract
    INDUSTRY AND POLICY NEWS

    National Stem Cell Foundation Travels with Axiom Space Mission to Continue Innovative Neurodegeneration Research on the International Space Station

    The Louisville-based National Stem Cell Foundation (NSCF) is a part of the third Axiom Space commercial astronaut mission to the International Space Station. This will be the fifth flight for NSCF’s Cosmic Brain Organoid project since 2018.
    [National Stem Cell Foundation (Business Wire)]

    Press Release
    FEATURED EVENT

    46th JSTCT Annual Meeting (JSTCT2024) Japanese Society for Transplantation and Cellular Therapy

    March 21 – 23, 2024
    Tokyo, Japan

    > See All Events

    JOB OPPORTUNITIES

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    STEMCELL Technologies – Vancouver, British Columbia, Canada

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    Columbia University Irving Medical Center – New York, New York, United States

    Research Associate – Metformin on Placenta

    University of Cambridge – Cambridge, England, United Kingdom

    Assistant Professor – Stem Cell Biology in Rare Diseases

    University of Alberta – Edmonton, Alberta, Canada

    Research Assistant – T Cell Biology & Human Immunology

    Karolinska Institutet – Solna, Sweden

    > See All Jobs

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